Ancillary therapy and supportive care of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on criteria for clinical trials in chronic graft-versus-host disease: V. ancillary therapy and supportive care working group report

Daniel Couriel, Paul A. Carpenter, Corey Cutler, F Javier Bolanos Meade, Nathaniel S. Treister, Juan Gea-Banacloche, Paul Shaughnessy, Sharon Hymes, Stella Kim, Alan S. Wayne, Jason W. Chien, Joyce Neumann, Sandra Mitchell, Karen Syrjala, Carina K. Moravec, Linda Abramovitz, Jerry Liebermann, Ann Berger, Lynn Gerber, Mary SchubertAlexandra H. Filipovich, Daniel Weisdorf, Mark M. Schubert, Howard Shulman, Kirk Schultz, Barbara Mittelman, Steven Pavletic, Georgia Boyce Vogelsang, Paul J. Martin, Stephanie J. Lee, Mary E D Flowers

Research output: Contribution to journalArticle


The Ancillary Therapy and Supportive Care Working Group had 3 goals: (1) to establish guidelines for ancillary therapy and supportive care in chronic graft-versus-host disease (GVHD), including treatment for symptoms and recommendations for patient education, preventive measures, and appropriate follow-up; (2) to provide guidelines for the prevention and management of infections and other common complications of treatment for chronic GVHD; and (3) to highlight the areas with the greatest need for clinical research. The definition of "ancillary therapy and supportive care" embraces the most frequent immunosuppressive or anti-inflammatory interventions used with topical intent and any other interventions directed at organ-specific control of symptoms or complications resulting from GVHD and its therapy. Also included in the definition are educational, preventive, and psychosocial interventions with this same objective. Recommendations are organized according to the strength and quality of evidence supporting them and cover the most commonly involved organs, including the skin, mouth, female genital tract, eyes, gastrointestinal tract, and lungs. Recommendations are provided for prevention of infections, osteoporosis, and steroid myopathy and management of neurocognitive and psychosocial adverse effects related to chronic GVHD. Optimal care of patients with chronic GVHD often requires a multidisciplinary approach.

Original languageEnglish (US)
Pages (from-to)375-396
Number of pages22
JournalBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Issue number4
Publication statusPublished - Apr 2006



  • Allogeneic cell transplantation
  • Chronic graft-versus-host disease
  • Consensus
  • Supportive care

ASJC Scopus subject areas

  • Transplantation

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