Anchors away! Fos fosters anchor-cell invasion

Denise J. Montell

doi:10.1016/j.cell.2005.06.003

Anchors away! Fos fosters anchor-cell invasion

Denise J. Montell

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

Invasion of cells through breakdown of the basement membrane is a crucial step during development and cancer metastasis. In this issue of Cell, Sherwood et al., (2005) describe a simple and genetically tractable cellular assay in the worm for elucidating the molecular processes that underlie cell invasion in vivo. They demonstrate that the transcription factor Fos is required for cell invasion and identify three of its downstream target genes (encoding a matrix metalloproteinase, hemicentin, and a fat-like protocadherin).

Original language	English (US)
Pages (from-to)	816-817
Number of pages	2
Journal	Cell
Volume	121
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2005.06.003
State	Published - Jun 17 2005
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2005.06.003

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abstract = "Invasion of cells through breakdown of the basement membrane is a crucial step during development and cancer metastasis. In this issue of Cell, Sherwood et al., (2005) describe a simple and genetically tractable cellular assay in the worm for elucidating the molecular processes that underlie cell invasion in vivo. They demonstrate that the transcription factor Fos is required for cell invasion and identify three of its downstream target genes (encoding a matrix metalloproteinase, hemicentin, and a fat-like protocadherin).",

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N2 - Invasion of cells through breakdown of the basement membrane is a crucial step during development and cancer metastasis. In this issue of Cell, Sherwood et al., (2005) describe a simple and genetically tractable cellular assay in the worm for elucidating the molecular processes that underlie cell invasion in vivo. They demonstrate that the transcription factor Fos is required for cell invasion and identify three of its downstream target genes (encoding a matrix metalloproteinase, hemicentin, and a fat-like protocadherin).

AB - Invasion of cells through breakdown of the basement membrane is a crucial step during development and cancer metastasis. In this issue of Cell, Sherwood et al., (2005) describe a simple and genetically tractable cellular assay in the worm for elucidating the molecular processes that underlie cell invasion in vivo. They demonstrate that the transcription factor Fos is required for cell invasion and identify three of its downstream target genes (encoding a matrix metalloproteinase, hemicentin, and a fat-like protocadherin).

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JO - Cell

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Anchors away! Fos fosters anchor-cell invasion

Abstract

ASJC Scopus subject areas

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