Ancestry of African Americans with sickle cell disease

Nadia Solovieff, Stephen W. Hartley, Clinton T. Baldwin, Elizabeth S. Klings, Mark T. Gladwin, James G. Taylor, Gregory J. Kato, Lindsay A. Farrer, Martin H. Steinberg, Paola Sebastiani

Research output: Contribution to journalArticlepeer-review

Abstract

The inheritance of genetic disease depends on ancestry that must be considered when interpreting genetic association studies and can provide insights when comparing traits in a population. We compared the genetic profiles of African Americans with sickle cell disease to those of Black Africans and Caucasian populations of European descent and found that they are less genetically admixed than other African Americans and have an ancestry similar to Yorubans, Mandenkas and Bantu.

Original languageEnglish (US)
Pages (from-to)41-45
Number of pages5
JournalBlood Cells, Molecules, and Diseases
Volume47
Issue number1
DOIs
StatePublished - Jun 15 2011

Keywords

  • Admixture
  • Genetic ancestry
  • Genetic association
  • Sickle cell disease

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Hematology
  • Cell Biology

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