Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla

P. A. Bottomley, H. R. Hart, W. A. Edelstein, J. F. Schenck, L. S. Smith, W. M. Leue, O. M. Mueller, R. W. Redington

Research output: Contribution to journalArticle

Abstract

Proton magnetic resonance (MR) images were obtained of the human head in magnetic fields as high as 1.5 Tesla (T) using slotted resonator high radio-frequency (RF) detection coils. The images showed no RF field penetration problems and exhibited an 11 (± 1)-fold improvement in signal-to-noise ratio over a .12-T imaging system. The first localized phosphorus 31, carbon 13, and proton MR chemical shift spectra recorded with surface coils from the head and body in the same instrument showed relative concentrations of phosphorus metabolites, triglycerides, and, when correlated with proton images, negligible lipid (-CH2-) signal from brain tissue on the time scale of the imaging experiment. Sugar phosphate and phosphodiester concentrations were significantly elevated in the head compared with muscle. This method should allow the combined assessment of anatomy, metabolism, and biochemistry in both the normal and diseased brain.

Original languageEnglish (US)
Pages (from-to)441-446
Number of pages6
JournalRADIOLOGY
Volume150
Issue number2
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Bottomley, P. A., Hart, H. R., Edelstein, W. A., Schenck, J. F., Smith, L. S., Leue, W. M., Mueller, O. M., & Redington, R. W. (1984). Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla. RADIOLOGY, 150(2), 441-446. https://doi.org/10.1148/radiology.150.2.6691099