Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla

P. A. Bottomley; H. R. Hart; W. A. Edelstein; J. F. Schenck; L. S. Smith; W. M. Leue; O. M. Mueller; R. W. Redington

doi:10.1148/radiology.150.2.6691099

Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla

P. A. Bottomley, H. R. Hart, W. A. Edelstein, J. F. Schenck, L. S. Smith, W. M. Leue, O. M. Mueller, R. W. Redington

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

Proton magnetic resonance (MR) images were obtained of the human head in magnetic fields as high as 1.5 Tesla (T) using slotted resonator high radio-frequency (RF) detection coils. The images showed no RF field penetration problems and exhibited an 11 (± 1)-fold improvement in signal-to-noise ratio over a .12-T imaging system. The first localized phosphorus 31, carbon 13, and proton MR chemical shift spectra recorded with surface coils from the head and body in the same instrument showed relative concentrations of phosphorus metabolites, triglycerides, and, when correlated with proton images, negligible lipid (-CH₂-) signal from brain tissue on the time scale of the imaging experiment. Sugar phosphate and phosphodiester concentrations were significantly elevated in the head compared with muscle. This method should allow the combined assessment of anatomy, metabolism, and biochemistry in both the normal and diseased brain.

Original language	English (US)
Pages (from-to)	441-446
Number of pages	6
Journal	RADIOLOGY
Volume	150
Issue number	2
DOIs	https://doi.org/10.1148/radiology.150.2.6691099
State	Published - Jan 1 1984
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1148/radiology.150.2.6691099

Cite this

@article{62ff2e0653ed4e78b243a12dcab2c37b,

title = "Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla",

abstract = "Proton magnetic resonance (MR) images were obtained of the human head in magnetic fields as high as 1.5 Tesla (T) using slotted resonator high radio-frequency (RF) detection coils. The images showed no RF field penetration problems and exhibited an 11 (± 1)-fold improvement in signal-to-noise ratio over a .12-T imaging system. The first localized phosphorus 31, carbon 13, and proton MR chemical shift spectra recorded with surface coils from the head and body in the same instrument showed relative concentrations of phosphorus metabolites, triglycerides, and, when correlated with proton images, negligible lipid (-CH2-) signal from brain tissue on the time scale of the imaging experiment. Sugar phosphate and phosphodiester concentrations were significantly elevated in the head compared with muscle. This method should allow the combined assessment of anatomy, metabolism, and biochemistry in both the normal and diseased brain.",

author = "Bottomley, {P. A.} and Hart, {H. R.} and Edelstein, {W. A.} and Schenck, {J. F.} and Smith, {L. S.} and Leue, {W. M.} and Mueller, {O. M.} and Redington, {R. W.}",

year = "1984",

month = jan,

day = "1",

doi = "10.1148/radiology.150.2.6691099",

language = "English (US)",

volume = "150",

pages = "441--446",

journal = "RADIOLOGY",

issn = "0033-8419",

publisher = "Radiological Society of North America Inc.",

number = "2",

}

TY - JOUR

T1 - Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla

AU - Bottomley, P. A.

AU - Hart, H. R.

AU - Edelstein, W. A.

AU - Schenck, J. F.

AU - Smith, L. S.

AU - Leue, W. M.

AU - Mueller, O. M.

AU - Redington, R. W.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - Proton magnetic resonance (MR) images were obtained of the human head in magnetic fields as high as 1.5 Tesla (T) using slotted resonator high radio-frequency (RF) detection coils. The images showed no RF field penetration problems and exhibited an 11 (± 1)-fold improvement in signal-to-noise ratio over a .12-T imaging system. The first localized phosphorus 31, carbon 13, and proton MR chemical shift spectra recorded with surface coils from the head and body in the same instrument showed relative concentrations of phosphorus metabolites, triglycerides, and, when correlated with proton images, negligible lipid (-CH2-) signal from brain tissue on the time scale of the imaging experiment. Sugar phosphate and phosphodiester concentrations were significantly elevated in the head compared with muscle. This method should allow the combined assessment of anatomy, metabolism, and biochemistry in both the normal and diseased brain.

AB - Proton magnetic resonance (MR) images were obtained of the human head in magnetic fields as high as 1.5 Tesla (T) using slotted resonator high radio-frequency (RF) detection coils. The images showed no RF field penetration problems and exhibited an 11 (± 1)-fold improvement in signal-to-noise ratio over a .12-T imaging system. The first localized phosphorus 31, carbon 13, and proton MR chemical shift spectra recorded with surface coils from the head and body in the same instrument showed relative concentrations of phosphorus metabolites, triglycerides, and, when correlated with proton images, negligible lipid (-CH2-) signal from brain tissue on the time scale of the imaging experiment. Sugar phosphate and phosphodiester concentrations were significantly elevated in the head compared with muscle. This method should allow the combined assessment of anatomy, metabolism, and biochemistry in both the normal and diseased brain.

UR - http://www.scopus.com/inward/record.url?scp=0021345957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021345957&partnerID=8YFLogxK

U2 - 10.1148/radiology.150.2.6691099

DO - 10.1148/radiology.150.2.6691099

M3 - Article

C2 - 6691099

AN - SCOPUS:0021345957

SN - 0033-8419

VL - 150

SP - 441

EP - 446

JO - RADIOLOGY

JF - RADIOLOGY

IS - 2

ER -

Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this