Anatomical structures, cell types and biomarkers of the Human Reference Atlas

Katy Börner; Sarah A. Teichmann; Ellen M. Quardokus; James C. Gee; Kristen Browne; David Osumi-Sutherland; Bruce W. Herr; Andreas Bueckle; Hrishikesh Paul; Muzlifah Haniffa; Laura Jardine; Amy Bernard; Song Lin Ding; Jeremy A. Miller; Shin Lin; Marc K. Halushka; Avinash Boppana; Teri A. Longacre; John Hickey; Yiing Lin; M. Todd Valerius; Yongqun He; Gloria Pryhuber; Xin Sun; Marda Jorgensen; Andrea J. Radtke; Clive Wasserfall; Fiona Ginty; Jonhan Ho; Joel Sunshine; Rebecca T. Beuschel; Maigan Brusko; Sujin Lee; Rajeev Malhotra; Sanjay Jain; Griffin Weber

doi:10.1038/s41556-021-00788-6

Anatomical structures, cell types and biomarkers of the Human Reference Atlas

Katy Börner, Sarah A. Teichmann, Ellen M. Quardokus, James C. Gee, Kristen Browne, David Osumi-Sutherland, Bruce W. Herr, Andreas Bueckle, Hrishikesh Paul, Muzlifah Haniffa, Laura Jardine, Amy Bernard, Song Lin Ding, Jeremy A. Miller, Shin Lin, Marc K. Halushka, Avinash Boppana, Teri A. Longacre, John Hickey, Yiing LinM. Todd Valerius, Yongqun He, Gloria Pryhuber, Xin Sun, Marda Jorgensen, Andrea J. Radtke, Clive Wasserfall, Fiona Ginty, Jonhan Ho, Joel Sunshine, Rebecca T. Beuschel, Maigan Brusko, Sujin Lee, Rajeev Malhotra, Sanjay Jain, Griffin Weber

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members of 16 international consortia on two essential and interlinked parts of the HRA: (1) three-dimensional representations of anatomy that are linked to (2) tables that name and interlink major anatomical structures, cell types, plus biomarkers (ASCT+B). We discuss four examples that demonstrate the practical utility of the HRA.

Original language	English (US)
Pages (from-to)	1117-1128
Number of pages	12
Journal	Nature cell biology
Volume	23
Issue number	11
DOIs	https://doi.org/10.1038/s41556-021-00788-6
State	Published - Nov 2021

ASJC Scopus subject areas

Cell Biology

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Börner, K., Teichmann, S. A., Quardokus, E. M., Gee, J. C., Browne, K., Osumi-Sutherland, D., Herr, B. W., Bueckle, A., Paul, H., Haniffa, M., Jardine, L., Bernard, A., Ding, S. L., Miller, J. A., Lin, S., Halushka, M. K., Boppana, A., Longacre, T. A., Hickey, J., ... Weber, G. (2021). Anatomical structures, cell types and biomarkers of the Human Reference Atlas. Nature cell biology, 23(11), 1117-1128. https://doi.org/10.1038/s41556-021-00788-6

Börner, K, Teichmann, SA, Quardokus, EM, Gee, JC, Browne, K, Osumi-Sutherland, D, Herr, BW, Bueckle, A, Paul, H, Haniffa, M, Jardine, L, Bernard, A, Ding, SL, Miller, JA, Lin, S, Halushka, MK, Boppana, A, Longacre, TA, Hickey, J, Lin, Y, Valerius, MT, He, Y, Pryhuber, G, Sun, X, Jorgensen, M, Radtke, AJ, Wasserfall, C, Ginty, F, Ho, J, Sunshine, J, Beuschel, RT, Brusko, M, Lee, S, Malhotra, R, Jain, S & Weber, G 2021, 'Anatomical structures, cell types and biomarkers of the Human Reference Atlas', Nature cell biology, vol. 23, no. 11, pp. 1117-1128. https://doi.org/10.1038/s41556-021-00788-6

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abstract = "The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members of 16 international consortia on two essential and interlinked parts of the HRA: (1) three-dimensional representations of anatomy that are linked to (2) tables that name and interlink major anatomical structures, cell types, plus biomarkers (ASCT+B). We discuss four examples that demonstrate the practical utility of the HRA.",

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AU - Browne, Kristen

AU - Osumi-Sutherland, David

AU - Herr, Bruce W.

AU - Bueckle, Andreas

AU - Paul, Hrishikesh

AU - Haniffa, Muzlifah

AU - Jardine, Laura

AU - Bernard, Amy

AU - Ding, Song Lin

AU - Miller, Jeremy A.

AU - Lin, Shin

AU - Halushka, Marc K.

AU - Boppana, Avinash

AU - Longacre, Teri A.

AU - Hickey, John

AU - Lin, Yiing

AU - Valerius, M. Todd

AU - He, Yongqun

AU - Pryhuber, Gloria

AU - Sun, Xin

AU - Jorgensen, Marda

AU - Radtke, Andrea J.

AU - Wasserfall, Clive

AU - Ginty, Fiona

AU - Ho, Jonhan

AU - Sunshine, Joel

AU - Beuschel, Rebecca T.

AU - Brusko, Maigan

AU - Lee, Sujin

AU - Malhotra, Rajeev

AU - Jain, Sanjay

AU - Weber, Griffin

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Anatomical structures, cell types and biomarkers of the Human Reference Atlas

Abstract

ASJC Scopus subject areas

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