Anatomical differences and network characteristics underlying smoking cue reactivity

Xiaochu Zhang, Betty Jo Salmeron, Thomas J. Ross, Hong Gu, Xiujuan Geng, Yihong Yang, Elliot A. Stein

Research output: Contribution to journalArticle

Abstract

A distributed network of brain regions is linked to drug-related cue responding. However, the relationships between smoking cue-induced phasic activity and possible underlying differences in brain structure, tonic neuronal activity and connectivity between these brain areas are as yet unclear. Twenty-two smokers and 22 controls viewed smoking-related and neutral pictures during a functional arterial spin labeling scanning session. T1, resting functional, and diffusion tensor imaging data were also collected. Six brain areas, dorsal lateral prefrontal cortex (dlPFC), dorsal medial prefrontal cortex (dmPFC), dorsal anterior cingulate cortex/cingulate cortex, rostral anterior cingulate cortex (rACC), occipital cortex, and insula/operculum, showed significant smoking cue-elicited activity in smokers when compared with controls and were subjected to secondary analysis for resting state functional connectivity (rsFC), structural, and tonic neuronal activity. rsFC strength between rACC and dlPFC was positively correlated with the cue-elicited activity in dlPFC. Similarly, rsFC strength between dlPFC and dmPFC was positively correlated with the cue-elicited activity in dmPFC while rsFC strength between dmPFC and insula/operculum was negatively correlated with the cue-elicited activity in both dmPFC and insula/operculum, suggesting these brain circuits may facilitate the response to the salient smoking cues. Further, the gray matter density in dlPFC was decreased in smokers and correlated with cue-elicited activity in the same brain area, suggesting a neurobiological mechanism for the impaired cognitive control associated with drug use. Taken together, these results begin to address the underlying neurobiology of smoking cue salience, and may speak to novel treatment strategies and targets for therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalNeuroImage
Volume54
Issue number1
DOIs
StatePublished - Jan 1 2011

Keywords

  • ASL
  • Anatomical
  • DTI
  • Resting state functional connectivity
  • Smoking cue
  • VBM

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Fingerprint Dive into the research topics of 'Anatomical differences and network characteristics underlying smoking cue reactivity'. Together they form a unique fingerprint.

  • Cite this

    Zhang, X., Salmeron, B. J., Ross, T. J., Gu, H., Geng, X., Yang, Y., & Stein, E. A. (2011). Anatomical differences and network characteristics underlying smoking cue reactivity. NeuroImage, 54(1), 131-141. https://doi.org/10.1016/j.neuroimage.2010.07.063