ANATOMICAL AND FUNCTIONAL OUTCOMES OF SYMPTOMATIC IDIOPATHIC VITREOMACULAR TRACTION

A Natural History Study From the Pan American Collaborative Retina Study Group

Lihteh Wu, Marcelo Zas, Maria H. Berrocal, J Fernando Arevalo, Marta Figueroa, Francisco Rodriguez, Martin Serrano, Federico Graue, Arturo Alezzandrini, Roberto Gallego-Pinazo, José A. Roca, Matias Iglicki, José Dalma-Weishauz, Igor Kozak, Alberto Collado, Josep Badal, Mauricio Maia, Guillermo Salcedo-Villanueva, Hugo Quiroz-Mercado, Jans Fromow-Guerra & 3 others David Lozano-Rechy, Marcos Avila, Jay Chhablani

Research output: Contribution to journalArticle

Abstract

RESULTS: There were 168 patients (51 men) with a mean age of 68.8 ± 10.7 years. Patients were followed for a mean of 22.7 ± 20.1 months. The mean duration of symptoms before the initial presentation was 3.65 ± 5.42 months. At baseline, 72 eyes had Grade 1, 74 eyes had Grade 2, and 22 eyes had Grade 3 SD-OCT findings. Over the follow-up period, 36 eyes (21.4%) had spontaneous resolution of the VMT with normalization of the foveal anatomy. The mean time to resolution was 12.3 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of the eyes, with 6 eyes developing a lamellar macular hole and 7 eyes developing a full-thickness macular hole. This occurred at a mean of 10.3 ± 10.7 months after the presentation. Subgroup analysis based on baseline SD-OCT grade showed that 4.1% (3 of 73) of Grade 1 eyes compared with 6.8% (5 of 74) of Grade 2 eyes, and 23.8% (5 of 21) of Grade 3 eyes developed a full-thickness macular hole or lamellar macular hole (P = 0.0109, chi-square test). In the remaining 119 eyes, at the last follow-up, 65 eyes had Grade 1, 42 eyes had Grade 2, and 12 eyes had Grade 3 VMT. On average, the best-corrected visual acuity improved from 0.40 ± 0.35 logarithm of the minimum angle of resolution (Snellen, 20/50) at baseline to 0.35 ± 0.36 logarithm of the minimum angle of resolution (Snellen, 20/45; P = 0.0372), and the mean central macular thickness improved from 350 ± 132 μm to 323 ± 121 μm.

CONCLUSION: Spontaneous resolution of VMT occurred in 21.4% (36 of 168) of eyes after a mean follow-up of 11.4 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of eyes. The baseline SD-OCT grade may predict the progression to full-thickness macular hole.

PURPOSE: To describe the natural history of eyes with symptomatic idiopathic vitreomacular traction (VMT).

METHODS: Retrospective multicenter study of 168 eyes with spectral-domain optical coherence tomography (SD-OCT) findings consistent with idiopathic VMT. All eyes were graded according to SD-OCT findings. Grade 1 was defined as incomplete cortical vitreous separation with foveal attachment. Grade 2 was defined as Grade 1 plus intraretinal cysts or clefts. Grade 3 was defined as Grade 2 plus a foveal detachment. All patients were followed for at least 6 months.

Original languageEnglish (US)
Pages (from-to)1913-1918
Number of pages6
JournalRetina (Philadelphia, Pa.)
Volume36
Issue number10
DOIs
StatePublished - Oct 1 2016

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Traction
Natural History
Retina
Retinal Perforations
Optical Coherence Tomography
Chi-Square Distribution

ASJC Scopus subject areas

  • Ophthalmology

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ANATOMICAL AND FUNCTIONAL OUTCOMES OF SYMPTOMATIC IDIOPATHIC VITREOMACULAR TRACTION : A Natural History Study From the Pan American Collaborative Retina Study Group. / Wu, Lihteh; Zas, Marcelo; Berrocal, Maria H.; Arevalo, J Fernando; Figueroa, Marta; Rodriguez, Francisco; Serrano, Martin; Graue, Federico; Alezzandrini, Arturo; Gallego-Pinazo, Roberto; Roca, José A.; Iglicki, Matias; Dalma-Weishauz, José; Kozak, Igor; Collado, Alberto; Badal, Josep; Maia, Mauricio; Salcedo-Villanueva, Guillermo; Quiroz-Mercado, Hugo; Fromow-Guerra, Jans; Lozano-Rechy, David; Avila, Marcos; Chhablani, Jay.

In: Retina (Philadelphia, Pa.), Vol. 36, No. 10, 01.10.2016, p. 1913-1918.

Research output: Contribution to journalArticle

Wu, L, Zas, M, Berrocal, MH, Arevalo, JF, Figueroa, M, Rodriguez, F, Serrano, M, Graue, F, Alezzandrini, A, Gallego-Pinazo, R, Roca, JA, Iglicki, M, Dalma-Weishauz, J, Kozak, I, Collado, A, Badal, J, Maia, M, Salcedo-Villanueva, G, Quiroz-Mercado, H, Fromow-Guerra, J, Lozano-Rechy, D, Avila, M & Chhablani, J 2016, 'ANATOMICAL AND FUNCTIONAL OUTCOMES OF SYMPTOMATIC IDIOPATHIC VITREOMACULAR TRACTION: A Natural History Study From the Pan American Collaborative Retina Study Group', Retina (Philadelphia, Pa.), vol. 36, no. 10, pp. 1913-1918. https://doi.org/10.1097/IAE.0000000000001015
Wu, Lihteh ; Zas, Marcelo ; Berrocal, Maria H. ; Arevalo, J Fernando ; Figueroa, Marta ; Rodriguez, Francisco ; Serrano, Martin ; Graue, Federico ; Alezzandrini, Arturo ; Gallego-Pinazo, Roberto ; Roca, José A. ; Iglicki, Matias ; Dalma-Weishauz, José ; Kozak, Igor ; Collado, Alberto ; Badal, Josep ; Maia, Mauricio ; Salcedo-Villanueva, Guillermo ; Quiroz-Mercado, Hugo ; Fromow-Guerra, Jans ; Lozano-Rechy, David ; Avila, Marcos ; Chhablani, Jay. / ANATOMICAL AND FUNCTIONAL OUTCOMES OF SYMPTOMATIC IDIOPATHIC VITREOMACULAR TRACTION : A Natural History Study From the Pan American Collaborative Retina Study Group. In: Retina (Philadelphia, Pa.). 2016 ; Vol. 36, No. 10. pp. 1913-1918.
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title = "ANATOMICAL AND FUNCTIONAL OUTCOMES OF SYMPTOMATIC IDIOPATHIC VITREOMACULAR TRACTION: A Natural History Study From the Pan American Collaborative Retina Study Group",
abstract = "RESULTS: There were 168 patients (51 men) with a mean age of 68.8 ± 10.7 years. Patients were followed for a mean of 22.7 ± 20.1 months. The mean duration of symptoms before the initial presentation was 3.65 ± 5.42 months. At baseline, 72 eyes had Grade 1, 74 eyes had Grade 2, and 22 eyes had Grade 3 SD-OCT findings. Over the follow-up period, 36 eyes (21.4{\%}) had spontaneous resolution of the VMT with normalization of the foveal anatomy. The mean time to resolution was 12.3 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7{\%} (13 of 168) of the eyes, with 6 eyes developing a lamellar macular hole and 7 eyes developing a full-thickness macular hole. This occurred at a mean of 10.3 ± 10.7 months after the presentation. Subgroup analysis based on baseline SD-OCT grade showed that 4.1{\%} (3 of 73) of Grade 1 eyes compared with 6.8{\%} (5 of 74) of Grade 2 eyes, and 23.8{\%} (5 of 21) of Grade 3 eyes developed a full-thickness macular hole or lamellar macular hole (P = 0.0109, chi-square test). In the remaining 119 eyes, at the last follow-up, 65 eyes had Grade 1, 42 eyes had Grade 2, and 12 eyes had Grade 3 VMT. On average, the best-corrected visual acuity improved from 0.40 ± 0.35 logarithm of the minimum angle of resolution (Snellen, 20/50) at baseline to 0.35 ± 0.36 logarithm of the minimum angle of resolution (Snellen, 20/45; P = 0.0372), and the mean central macular thickness improved from 350 ± 132 μm to 323 ± 121 μm.CONCLUSION: Spontaneous resolution of VMT occurred in 21.4{\%} (36 of 168) of eyes after a mean follow-up of 11.4 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7{\%} (13 of 168) of eyes. The baseline SD-OCT grade may predict the progression to full-thickness macular hole.PURPOSE: To describe the natural history of eyes with symptomatic idiopathic vitreomacular traction (VMT).METHODS: Retrospective multicenter study of 168 eyes with spectral-domain optical coherence tomography (SD-OCT) findings consistent with idiopathic VMT. All eyes were graded according to SD-OCT findings. Grade 1 was defined as incomplete cortical vitreous separation with foveal attachment. Grade 2 was defined as Grade 1 plus intraretinal cysts or clefts. Grade 3 was defined as Grade 2 plus a foveal detachment. All patients were followed for at least 6 months.",
author = "Lihteh Wu and Marcelo Zas and Berrocal, {Maria H.} and Arevalo, {J Fernando} and Marta Figueroa and Francisco Rodriguez and Martin Serrano and Federico Graue and Arturo Alezzandrini and Roberto Gallego-Pinazo and Roca, {Jos{\'e} A.} and Matias Iglicki and Jos{\'e} Dalma-Weishauz and Igor Kozak and Alberto Collado and Josep Badal and Mauricio Maia and Guillermo Salcedo-Villanueva and Hugo Quiroz-Mercado and Jans Fromow-Guerra and David Lozano-Rechy and Marcos Avila and Jay Chhablani",
year = "2016",
month = "10",
day = "1",
doi = "10.1097/IAE.0000000000001015",
language = "English (US)",
volume = "36",
pages = "1913--1918",
journal = "Retina",
issn = "0275-004X",
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TY - JOUR

T1 - ANATOMICAL AND FUNCTIONAL OUTCOMES OF SYMPTOMATIC IDIOPATHIC VITREOMACULAR TRACTION

T2 - A Natural History Study From the Pan American Collaborative Retina Study Group

AU - Wu, Lihteh

AU - Zas, Marcelo

AU - Berrocal, Maria H.

AU - Arevalo, J Fernando

AU - Figueroa, Marta

AU - Rodriguez, Francisco

AU - Serrano, Martin

AU - Graue, Federico

AU - Alezzandrini, Arturo

AU - Gallego-Pinazo, Roberto

AU - Roca, José A.

AU - Iglicki, Matias

AU - Dalma-Weishauz, José

AU - Kozak, Igor

AU - Collado, Alberto

AU - Badal, Josep

AU - Maia, Mauricio

AU - Salcedo-Villanueva, Guillermo

AU - Quiroz-Mercado, Hugo

AU - Fromow-Guerra, Jans

AU - Lozano-Rechy, David

AU - Avila, Marcos

AU - Chhablani, Jay

PY - 2016/10/1

Y1 - 2016/10/1

N2 - RESULTS: There were 168 patients (51 men) with a mean age of 68.8 ± 10.7 years. Patients were followed for a mean of 22.7 ± 20.1 months. The mean duration of symptoms before the initial presentation was 3.65 ± 5.42 months. At baseline, 72 eyes had Grade 1, 74 eyes had Grade 2, and 22 eyes had Grade 3 SD-OCT findings. Over the follow-up period, 36 eyes (21.4%) had spontaneous resolution of the VMT with normalization of the foveal anatomy. The mean time to resolution was 12.3 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of the eyes, with 6 eyes developing a lamellar macular hole and 7 eyes developing a full-thickness macular hole. This occurred at a mean of 10.3 ± 10.7 months after the presentation. Subgroup analysis based on baseline SD-OCT grade showed that 4.1% (3 of 73) of Grade 1 eyes compared with 6.8% (5 of 74) of Grade 2 eyes, and 23.8% (5 of 21) of Grade 3 eyes developed a full-thickness macular hole or lamellar macular hole (P = 0.0109, chi-square test). In the remaining 119 eyes, at the last follow-up, 65 eyes had Grade 1, 42 eyes had Grade 2, and 12 eyes had Grade 3 VMT. On average, the best-corrected visual acuity improved from 0.40 ± 0.35 logarithm of the minimum angle of resolution (Snellen, 20/50) at baseline to 0.35 ± 0.36 logarithm of the minimum angle of resolution (Snellen, 20/45; P = 0.0372), and the mean central macular thickness improved from 350 ± 132 μm to 323 ± 121 μm.CONCLUSION: Spontaneous resolution of VMT occurred in 21.4% (36 of 168) of eyes after a mean follow-up of 11.4 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of eyes. The baseline SD-OCT grade may predict the progression to full-thickness macular hole.PURPOSE: To describe the natural history of eyes with symptomatic idiopathic vitreomacular traction (VMT).METHODS: Retrospective multicenter study of 168 eyes with spectral-domain optical coherence tomography (SD-OCT) findings consistent with idiopathic VMT. All eyes were graded according to SD-OCT findings. Grade 1 was defined as incomplete cortical vitreous separation with foveal attachment. Grade 2 was defined as Grade 1 plus intraretinal cysts or clefts. Grade 3 was defined as Grade 2 plus a foveal detachment. All patients were followed for at least 6 months.

AB - RESULTS: There were 168 patients (51 men) with a mean age of 68.8 ± 10.7 years. Patients were followed for a mean of 22.7 ± 20.1 months. The mean duration of symptoms before the initial presentation was 3.65 ± 5.42 months. At baseline, 72 eyes had Grade 1, 74 eyes had Grade 2, and 22 eyes had Grade 3 SD-OCT findings. Over the follow-up period, 36 eyes (21.4%) had spontaneous resolution of the VMT with normalization of the foveal anatomy. The mean time to resolution was 12.3 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of the eyes, with 6 eyes developing a lamellar macular hole and 7 eyes developing a full-thickness macular hole. This occurred at a mean of 10.3 ± 10.7 months after the presentation. Subgroup analysis based on baseline SD-OCT grade showed that 4.1% (3 of 73) of Grade 1 eyes compared with 6.8% (5 of 74) of Grade 2 eyes, and 23.8% (5 of 21) of Grade 3 eyes developed a full-thickness macular hole or lamellar macular hole (P = 0.0109, chi-square test). In the remaining 119 eyes, at the last follow-up, 65 eyes had Grade 1, 42 eyes had Grade 2, and 12 eyes had Grade 3 VMT. On average, the best-corrected visual acuity improved from 0.40 ± 0.35 logarithm of the minimum angle of resolution (Snellen, 20/50) at baseline to 0.35 ± 0.36 logarithm of the minimum angle of resolution (Snellen, 20/45; P = 0.0372), and the mean central macular thickness improved from 350 ± 132 μm to 323 ± 121 μm.CONCLUSION: Spontaneous resolution of VMT occurred in 21.4% (36 of 168) of eyes after a mean follow-up of 11.4 ± 12.6 months. An unfavorable anatomical outcome occurred in 7.7% (13 of 168) of eyes. The baseline SD-OCT grade may predict the progression to full-thickness macular hole.PURPOSE: To describe the natural history of eyes with symptomatic idiopathic vitreomacular traction (VMT).METHODS: Retrospective multicenter study of 168 eyes with spectral-domain optical coherence tomography (SD-OCT) findings consistent with idiopathic VMT. All eyes were graded according to SD-OCT findings. Grade 1 was defined as incomplete cortical vitreous separation with foveal attachment. Grade 2 was defined as Grade 1 plus intraretinal cysts or clefts. Grade 3 was defined as Grade 2 plus a foveal detachment. All patients were followed for at least 6 months.

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