Anatomical and electrophysiological comparison of the sensory innervation of bronchial and tracheal parasympathetic ganglion neurons

Allen Myers, Bradley Undem, Wolfgang Kummer

Research output: Contribution to journalArticle

Abstract

Anatomical and electrophysiological techniques were used to examine differences in the level of sensory nerve terminals localized in parasympathetic ganglia in guinea pig trachea and bronchus. We quantified substance-P-immunoreactive nerve terminal profiles within the ganglia and the amplitude of capsaicin-sensitive depolarization (slow excitatory postsynaptic potential or sEPSP) evoked by vagus (bronchial) or recurrent (tracheal) nerve-stimulation. Substance-P-immunoreactive axon profiles per intrinsic tracheal neuron were fewer in number than per bronchial ganglion neuron. The average amplitude and duration of the capsaicin-sensitive sEPSPs were similar in tracheal and bronchial ganglion neurons. Furthermore, capsaicin evoked a nearly equal depolarization of bronchial and tracheal ganglion neurons. The sEPSPs were reduced in both areas by a selective neurokinin-3 receptor antagonist, SR142801. These results demonstrate that although the number of sensory nerve fibers in tracheal ganglia are significantly less than those in the bronchus, this did not translate to an obvious physiological difference in sEPSP amplitude.

Original languageEnglish (US)
Pages (from-to)162-168
Number of pages7
JournalJournal of the Autonomic Nervous System
Volume61
Issue number2
DOIs
StatePublished - Nov 6 1996

Keywords

  • Afferent
  • Axon reflex
  • Bronchus
  • C-fiber
  • Capsaicin
  • Neurokinin-3 receptors
  • Neurokinins
  • Trachea

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Clinical Neurology

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