Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus

Kylie S. Chew, Diego C. Fernandez, Samer Hattar, Thomas C. Südhof, David C. Martinelli

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Many biochemical, physiological, and behavioral processes such as glucose metabolism, body temperature, and sleep-wake cycles show regular daily rhythms. These circadian rhythms are adjusted to the environmental light-dark cycle by a central pacemaker located in the suprachiasmatic nucleus (SCN) in order for the processes to occur at appropriate times of day. Here, we investigated the expression and function of a synaptic organizing protein, C1QL3, in the SCN. We found that C1ql3 is robustly expressed in the SCN. C1ql3 knockout mice have a reduced density of excitatory synapses in the SCN. In addition, these mice exhibited less consolidated activity to the active portions of the day and period lengthening following a 15-minute phase-delaying light pulse. These data identify C1QL3 as a signaling molecule that is highly expressed in SCN neurons, where it contributes to the formation and/or maintenance of glutamatergic synapses and plays a role in circadian behaviors, which may include circadian aftereffects.

Original languageEnglish (US)
Pages (from-to)222-236
Number of pages15
JournalJournal of Biological Rhythms
Issue number3
StatePublished - Jun 1 2017


  • C1q-like
  • C1ql
  • C1ql3
  • SCN
  • aftereffects
  • circadian
  • rhythms
  • suprachiasmatic nucleus
  • synapse

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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