Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus

Kylie S. Chew, Diego C. Fernandez, Samer Hattar, Thomas C. Südhof, David C. Martinelli

Research output: Contribution to journalArticle

Abstract

Many biochemical, physiological, and behavioral processes such as glucose metabolism, body temperature, and sleep-wake cycles show regular daily rhythms. These circadian rhythms are adjusted to the environmental light-dark cycle by a central pacemaker located in the suprachiasmatic nucleus (SCN) in order for the processes to occur at appropriate times of day. Here, we investigated the expression and function of a synaptic organizing protein, C1QL3, in the SCN. We found that C1ql3 is robustly expressed in the SCN. C1ql3 knockout mice have a reduced density of excitatory synapses in the SCN. In addition, these mice exhibited less consolidated activity to the active portions of the day and period lengthening following a 15-minute phase-delaying light pulse. These data identify C1QL3 as a signaling molecule that is highly expressed in SCN neurons, where it contributes to the formation and/or maintenance of glutamatergic synapses and plays a role in circadian behaviors, which may include circadian aftereffects.

LanguageEnglish (US)
Pages222-236
Number of pages15
JournalJournal of Biological Rhythms
Volume32
Issue number3
DOIs
StatePublished - Jun 1 2017

Fingerprint

Suprachiasmatic Nucleus
Synapses
Physiological Phenomena
Photoperiod
Circadian Rhythm
Body Temperature
Knockout Mice
Sleep
Maintenance
Neurons
Light
Glucose
Proteins

Keywords

  • aftereffects
  • C1q-like
  • C1ql
  • C1ql3
  • circadian
  • rhythms
  • SCN
  • suprachiasmatic nucleus
  • synapse

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Chew, K. S., Fernandez, D. C., Hattar, S., Südhof, T. C., & Martinelli, D. C. (2017). Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus. Journal of Biological Rhythms, 32(3), 222-236. DOI: 10.1177/0748730417704766

Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus. / Chew, Kylie S.; Fernandez, Diego C.; Hattar, Samer; Südhof, Thomas C.; Martinelli, David C.

In: Journal of Biological Rhythms, Vol. 32, No. 3, 01.06.2017, p. 222-236.

Research output: Contribution to journalArticle

Chew, KS, Fernandez, DC, Hattar, S, Südhof, TC & Martinelli, DC 2017, 'Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus' Journal of Biological Rhythms, vol 32, no. 3, pp. 222-236. DOI: 10.1177/0748730417704766
Chew KS, Fernandez DC, Hattar S, Südhof TC, Martinelli DC. Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus. Journal of Biological Rhythms. 2017 Jun 1;32(3):222-236. Available from, DOI: 10.1177/0748730417704766
Chew, Kylie S. ; Fernandez, Diego C. ; Hattar, Samer ; Südhof, Thomas C. ; Martinelli, David C./ Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus. In: Journal of Biological Rhythms. 2017 ; Vol. 32, No. 3. pp. 222-236
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