Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder

F. Xavier Castellanos, Wendy S. Sharp, Rebecca F Gottesman, Deanna K. Greenstein, Jay N. Giedd, Judith L. Rapoport

Research output: Contribution to journalArticle


Objective: To examine brain-behavior relationships in attention deficit hyperactivity disorder (ADHD), the authors obtained magnetic resonance imaging (MRI) scans of monozygotic twins discordant for ADHD. Method: National recruitment was followed by in-person assessment. MRI scans were measured algorithmically for nine pairs of monozygotic twins discordant for ADHD. Results: The affected twins had significantly smaller caudate volumes (mean difference=-0.56 ml, CI=-0.92 to -0.21) than their unaffected co-twins. Conclusions: These results provide further support for striatal models of ADHD pathophysiology.

Original languageEnglish (US)
Pages (from-to)1693-1696
Number of pages4
JournalAmerican Journal of Psychiatry
Issue number9
Publication statusPublished - Sep 2003
Externally publishedYes


ASJC Scopus subject areas

  • Psychiatry and Mental health

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