Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder

F. Xavier Castellanos; Wendy S. Sharp; Rebecca F. Gottesman; Deanna K. Greenstein; Jay N. Giedd; Judith L. Rapoport

doi:10.1176/appi.ajp.160.9.1693

Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder

F. Xavier Castellanos, Wendy S. Sharp, Rebecca F. Gottesman, Deanna K. Greenstein, Jay N. Giedd, Judith L. Rapoport

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To examine brain-behavior relationships in attention deficit hyperactivity disorder (ADHD), the authors obtained magnetic resonance imaging (MRI) scans of monozygotic twins discordant for ADHD. Method: National recruitment was followed by in-person assessment. MRI scans were measured algorithmically for nine pairs of monozygotic twins discordant for ADHD. Results: The affected twins had significantly smaller caudate volumes (mean difference=-0.56 ml, CI=-0.92 to -0.21) than their unaffected co-twins. Conclusions: These results provide further support for striatal models of ADHD pathophysiology.

Original language	English (US)
Pages (from-to)	1693-1696
Number of pages	4
Journal	American Journal of Psychiatry
Volume	160
Issue number	9
DOIs	https://doi.org/10.1176/appi.ajp.160.9.1693
State	Published - Sep 2003
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health

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Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder. / Castellanos, F. Xavier; Sharp, Wendy S.; Gottesman, Rebecca F.; Greenstein, Deanna K.; Giedd, Jay N.; Rapoport, Judith L.

In: American Journal of Psychiatry, Vol. 160, No. 9, 09.2003, p. 1693-1696.

Research output: Contribution to journal › Article › peer-review

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AU - Rapoport, Judith L.

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