TY - JOUR
T1 - Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder
AU - Castellanos, F. Xavier
AU - Sharp, Wendy S.
AU - Gottesman, Rebecca F.
AU - Greenstein, Deanna K.
AU - Giedd, Jay N.
AU - Rapoport, Judith L.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/9
Y1 - 2003/9
N2 - Objective: To examine brain-behavior relationships in attention deficit hyperactivity disorder (ADHD), the authors obtained magnetic resonance imaging (MRI) scans of monozygotic twins discordant for ADHD. Method: National recruitment was followed by in-person assessment. MRI scans were measured algorithmically for nine pairs of monozygotic twins discordant for ADHD. Results: The affected twins had significantly smaller caudate volumes (mean difference=-0.56 ml, CI=-0.92 to -0.21) than their unaffected co-twins. Conclusions: These results provide further support for striatal models of ADHD pathophysiology.
AB - Objective: To examine brain-behavior relationships in attention deficit hyperactivity disorder (ADHD), the authors obtained magnetic resonance imaging (MRI) scans of monozygotic twins discordant for ADHD. Method: National recruitment was followed by in-person assessment. MRI scans were measured algorithmically for nine pairs of monozygotic twins discordant for ADHD. Results: The affected twins had significantly smaller caudate volumes (mean difference=-0.56 ml, CI=-0.92 to -0.21) than their unaffected co-twins. Conclusions: These results provide further support for striatal models of ADHD pathophysiology.
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U2 - 10.1176/appi.ajp.160.9.1693
DO - 10.1176/appi.ajp.160.9.1693
M3 - Article
C2 - 12944348
AN - SCOPUS:0642343889
VL - 160
SP - 1693
EP - 1696
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 9
ER -