Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder

F. Xavier Castellanos; Wendy S. Sharp; Rebecca F Gottesman; Deanna K. Greenstein; Jay N. Giedd; Judith L. Rapoport

doi:10.1176/appi.ajp.160.9.1693

Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder

F. Xavier Castellanos, Wendy S. Sharp, Rebecca F Gottesman, Deanna K. Greenstein, Jay N. Giedd, Judith L. Rapoport

Research output: Contribution to journal › Article

Abstract

Objective: To examine brain-behavior relationships in attention deficit hyperactivity disorder (ADHD), the authors obtained magnetic resonance imaging (MRI) scans of monozygotic twins discordant for ADHD. Method: National recruitment was followed by in-person assessment. MRI scans were measured algorithmically for nine pairs of monozygotic twins discordant for ADHD. Results: The affected twins had significantly smaller caudate volumes (mean difference=-0.56 ml, CI=-0.92 to -0.21) than their unaffected co-twins. Conclusions: These results provide further support for striatal models of ADHD pathophysiology.

Original language	English (US)
Pages (from-to)	1693-1696
Number of pages	4
Journal	American Journal of Psychiatry
Volume	160
Issue number	9
DOIs	https://doi.org/10.1176/appi.ajp.160.9.1693
Publication status	Published - Sep 2003
Externally published	Yes

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ASJC Scopus subject areas

Psychiatry and Mental health

Cite this

Castellanos, F. X., Sharp, W. S., Gottesman, R. F., Greenstein, D. K., Giedd, J. N., & Rapoport, J. L. (2003). Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder. American Journal of Psychiatry, 160(9), 1693-1696. https://doi.org/10.1176/appi.ajp.160.9.1693

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10.1176/appi.ajp.160.9.1693