Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder

F. Xavier Castellanos, Wendy S. Sharp, Rebecca F. Gottesman, Deanna K. Greenstein, Jay N. Giedd, Judith L. Rapoport

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To examine brain-behavior relationships in attention deficit hyperactivity disorder (ADHD), the authors obtained magnetic resonance imaging (MRI) scans of monozygotic twins discordant for ADHD. Method: National recruitment was followed by in-person assessment. MRI scans were measured algorithmically for nine pairs of monozygotic twins discordant for ADHD. Results: The affected twins had significantly smaller caudate volumes (mean difference=-0.56 ml, CI=-0.92 to -0.21) than their unaffected co-twins. Conclusions: These results provide further support for striatal models of ADHD pathophysiology.

Original languageEnglish (US)
Pages (from-to)1693-1696
Number of pages4
JournalAmerican Journal of Psychiatry
Volume160
Issue number9
DOIs
StatePublished - Sep 2003
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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