Anaplasma phagocytophilum, interferon gamma production and Stat1 signaling

Kyoung Seong Choi, J. Stephen Dumler

Research output: Contribution to journalArticlepeer-review

Abstract

Human granulocytic anaplasmosis is caused by the obligate intracellular bacterium, Anaplasma phagocytophilum. The proinflammatory cytokine, IFN-γ, is necessary for innate immunity and plays an important role in the induction of severe histopathology in A. phagocytophilum-infected mice, horses and humans. In this study, activation of signal transducer and activator of transcription (Stat) 1 phosphorylation associated with A. phagocytophilum infection was examined in mice and found to be markedly greater on day 7 post-infection than in mock-infected controls. This increase in phosphorylated Stat1 (pStat1) correlated significantly with IFN-γ production and inflammatory tissue injury. Because pStat1 operates as a transcription factor central to the generation of effectors of inflammatory injury, these data suggest that Stat1 signaling is involved in IFN-γ-mediated immunopathologic lesions and disease in A. phagocytophilum infection and could be an important target for intervention in this disease.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalMicrobiology and Immunology
Volume57
Issue number3
DOIs
StatePublished - Mar 2013

Keywords

  • Anaplasma phagocytophilum
  • Gamma interferon
  • Signal transducer and activator of transcription 1

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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