Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

Kyoung Seong Choi; Dennis J. Grab; J. Stephen Dumler

doi:10.1128/IAI.72.6.3680-3683.2004

Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

Kyoung Seong Choi, Dennis J. Grab, J. Stephen Dumler

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

Original language	English (US)
Pages (from-to)	3680-3683
Number of pages	4
Journal	Infection and immunity
Volume	72
Issue number	6
DOIs	https://doi.org/10.1128/IAI.72.6.3680-3683.2004
State	Published - Jun 2004
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

Access to Document

10.1128/IAI.72.6.3680-3683.2004

Cite this

@article{013d114f1fdc4675bf249a7e51ceb6f0,

title = "Anaplasma phagocytophilum infection induces protracted neutrophil degranulation",

abstract = "Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.",

author = "Choi, {Kyoung Seong} and Grab, {Dennis J.} and Dumler, {J. Stephen}",

year = "2004",

month = jun,

doi = "10.1128/IAI.72.6.3680-3683.2004",

language = "English (US)",

volume = "72",

pages = "3680--3683",

journal = "Infection and immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "6",

}

TY - JOUR

T1 - Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

AU - Choi, Kyoung Seong

AU - Grab, Dennis J.

AU - Dumler, J. Stephen

PY - 2004/6

Y1 - 2004/6

N2 - Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

AB - Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

UR - http://www.scopus.com/inward/record.url?scp=2542576378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2542576378&partnerID=8YFLogxK

U2 - 10.1128/IAI.72.6.3680-3683.2004

DO - 10.1128/IAI.72.6.3680-3683.2004

M3 - Article

C2 - 15155684

AN - SCOPUS:2542576378

SN - 0019-9567

VL - 72

SP - 3680

EP - 3683

JO - Infection and immunity

JF - Infection and immunity

IS - 6

ER -

Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this