Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

Kyoung Seong Choi, Dennis J. Grab, J. Stephen Dumler

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

Original languageEnglish (US)
Pages (from-to)3680-3683
Number of pages4
JournalInfection and immunity
Issue number6
StatePublished - Jun 2004
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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