Anafilassi

Anaphylaxis results from an abrupt and massive release of different mediators through IgE or non-IgE-mediated activation of mastcells or basophils. Clinical manifestations begin to develop soon after exposure to the triggering agent and may be represented by premonitory symptoms. Major or minor clinical features of anaphylaxis prominently involve the airways, the cardiovascular system, the gastrointestinal system, the nervous system and the skin; shock, cardiac arrest, bronchospasm and laryngeal aedema are the most threatening consequences of an anaphylactic reaction. The cornerstones of treatment of anaphylactic shock are: ventilation and oxygen, colloid solutions infusion, subcutaneous or intravenous administration of epinephrine and, if necessary, other sympathomimetic agents (dopamine or norepinephrine).