Analyzing absorption and scattering spectra of micro-scale structures with spectroscopic optical coherence tomography

Ji Yi, Jianmin Gong, Xu Li

Research output: Contribution to journalArticlepeer-review

Abstract

We demonstrate the feasibility of characterizing the absorption and scattering spectra of micron-scale structures in a turbid medium using a spectroscopic optical coherence tomography (SOCT) system with a bandwidth of 430-650nm. SOCT measurements are taken from phantoms composed of fluorescent microspheres. The absorption and scattering spectra are recovered with proper selections of spatial window width in the post processing step. Furthermore, we present an analysis using numerical OCT simulation based on full-wave solutions of the Maxwell's Equation to elucidate the origination of the multiple peaks in the OCT image for a single microsphere. Finally, we demonstrate the possibility of identifying contrast agents concentrated in micron-sized scale in an SOCT image. Two different types of microspheres in gel phantom are discriminated in 3D volume based on their distinguished absorbent feature.

Original languageEnglish (US)
Pages (from-to)13157-13167
Number of pages11
JournalOptics Express
Volume17
Issue number15
DOIs
StatePublished - Jul 20 2009
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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