Abstract
The mean time spent by photons inside a nonlocalized optically abnormal embedded inclusion has been derived analytically. The accuracy of the results has been tested against Monte Carlo and experimental data. We show that for quantification of the absorption coefficient of absorptive inclusions, a corrective factor that takes into account the size of the inclusion is needed. This finding suggests that perturbation methods derived for very small inclusions which are used in inverse algorithms require a corrective factor to adequately quantify the differential absorption coefficient of nonlocalized targets embedded in optically turbid media.
Original language | English (US) |
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Pages (from-to) | 486-492 |
Number of pages | 7 |
Journal | Journal of biomedical optics |
Volume | 7 |
Issue number | 3 |
DOIs | |
State | Published - Jul 2002 |
Externally published | Yes |
Keywords
- Differential absorption
- Optical imaging
- Photon migration
- Time of flight
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Biomedical Engineering