Analysis of transmural trends in myocardial integrated backscatter in patients with progressive systemic sclerosis

Keiji Hirooka, Johji Naito, Yukihiro Koretsune, Hiroaki Irino, Haruhiko Abe, Minoru Ichikawa, Yoshinori Yasuoka, Hiroyoshi Yamamoto, Katsuji Hashimoto, Wakatomi Chin, Hideo Kusuoka, Michitoshi Inoue, Masatsugu Hori

Research output: Contribution to journalArticle

Abstract

Cardiac involvement in progressive systemic sclerosis (PSS) is common and has a strong negative impact on the prognosis, especially when autoantibodies are present. To determine whether ultrasonic tissue characterization can detect early ultrastructural changes in the sclerodermal myocardium, we analyzed the transmural heterogeneity in myocardial integrated backscatter (THIB). "A-THIB" was defined as the absolute difference in integrated backscatter between the left (subendocardial) and right (subepicardial) ventricular halves of the myocardium in the septum and posterior wall, and was measured in 11 patients with PSS and 10 age- and sex-matched healthy participants. A-THIB in patients with PSS was higher than that in healthy participants (1.3 ± 1.3 vs 4.0 ± 1.4 dB for the septum and 1.1 ± 0.7 dB vs 2.8 ± 0.4 dB for the posterior wall; mean ± SD, respectively, P <.0005). Septal A-THIB was higher in patients with PSS with than without anti-Scl70 or antinucleolar antibodies (3.2 ± 1.1 vs 5.0 ± 1.0 dB, P = .0165). Early changes in the myocardium of patients with PSS, possibly related to increased interstitial collagen deposition, can be detected by quantitative analysis of THIB.

Original languageEnglish (US)
Pages (from-to)340-346
Number of pages7
JournalJournal of the American Society of Echocardiography
Volume16
Issue number4
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

Fingerprint

Diffuse Scleroderma
Myocardium
Healthy Volunteers
Ultrasonics
Autoantibodies
Collagen
Antibodies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Analysis of transmural trends in myocardial integrated backscatter in patients with progressive systemic sclerosis. / Hirooka, Keiji; Naito, Johji; Koretsune, Yukihiro; Irino, Hiroaki; Abe, Haruhiko; Ichikawa, Minoru; Yasuoka, Yoshinori; Yamamoto, Hiroyoshi; Hashimoto, Katsuji; Chin, Wakatomi; Kusuoka, Hideo; Inoue, Michitoshi; Hori, Masatsugu.

In: Journal of the American Society of Echocardiography, Vol. 16, No. 4, 01.04.2003, p. 340-346.

Research output: Contribution to journalArticle

Hirooka, K, Naito, J, Koretsune, Y, Irino, H, Abe, H, Ichikawa, M, Yasuoka, Y, Yamamoto, H, Hashimoto, K, Chin, W, Kusuoka, H, Inoue, M & Hori, M 2003, 'Analysis of transmural trends in myocardial integrated backscatter in patients with progressive systemic sclerosis', Journal of the American Society of Echocardiography, vol. 16, no. 4, pp. 340-346. https://doi.org/10.1016/S0894-7317(02)74427-1
Hirooka, Keiji ; Naito, Johji ; Koretsune, Yukihiro ; Irino, Hiroaki ; Abe, Haruhiko ; Ichikawa, Minoru ; Yasuoka, Yoshinori ; Yamamoto, Hiroyoshi ; Hashimoto, Katsuji ; Chin, Wakatomi ; Kusuoka, Hideo ; Inoue, Michitoshi ; Hori, Masatsugu. / Analysis of transmural trends in myocardial integrated backscatter in patients with progressive systemic sclerosis. In: Journal of the American Society of Echocardiography. 2003 ; Vol. 16, No. 4. pp. 340-346.
@article{84e684d95f6241938d444f328f9c0222,
title = "Analysis of transmural trends in myocardial integrated backscatter in patients with progressive systemic sclerosis",
abstract = "Cardiac involvement in progressive systemic sclerosis (PSS) is common and has a strong negative impact on the prognosis, especially when autoantibodies are present. To determine whether ultrasonic tissue characterization can detect early ultrastructural changes in the sclerodermal myocardium, we analyzed the transmural heterogeneity in myocardial integrated backscatter (THIB). {"}A-THIB{"} was defined as the absolute difference in integrated backscatter between the left (subendocardial) and right (subepicardial) ventricular halves of the myocardium in the septum and posterior wall, and was measured in 11 patients with PSS and 10 age- and sex-matched healthy participants. A-THIB in patients with PSS was higher than that in healthy participants (1.3 ± 1.3 vs 4.0 ± 1.4 dB for the septum and 1.1 ± 0.7 dB vs 2.8 ± 0.4 dB for the posterior wall; mean ± SD, respectively, P <.0005). Septal A-THIB was higher in patients with PSS with than without anti-Scl70 or antinucleolar antibodies (3.2 ± 1.1 vs 5.0 ± 1.0 dB, P = .0165). Early changes in the myocardium of patients with PSS, possibly related to increased interstitial collagen deposition, can be detected by quantitative analysis of THIB.",
author = "Keiji Hirooka and Johji Naito and Yukihiro Koretsune and Hiroaki Irino and Haruhiko Abe and Minoru Ichikawa and Yoshinori Yasuoka and Hiroyoshi Yamamoto and Katsuji Hashimoto and Wakatomi Chin and Hideo Kusuoka and Michitoshi Inoue and Masatsugu Hori",
year = "2003",
month = "4",
day = "1",
doi = "10.1016/S0894-7317(02)74427-1",
language = "English (US)",
volume = "16",
pages = "340--346",
journal = "Journal of the American Society of Echocardiography",
issn = "0894-7317",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Analysis of transmural trends in myocardial integrated backscatter in patients with progressive systemic sclerosis

AU - Hirooka, Keiji

AU - Naito, Johji

AU - Koretsune, Yukihiro

AU - Irino, Hiroaki

AU - Abe, Haruhiko

AU - Ichikawa, Minoru

AU - Yasuoka, Yoshinori

AU - Yamamoto, Hiroyoshi

AU - Hashimoto, Katsuji

AU - Chin, Wakatomi

AU - Kusuoka, Hideo

AU - Inoue, Michitoshi

AU - Hori, Masatsugu

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Cardiac involvement in progressive systemic sclerosis (PSS) is common and has a strong negative impact on the prognosis, especially when autoantibodies are present. To determine whether ultrasonic tissue characterization can detect early ultrastructural changes in the sclerodermal myocardium, we analyzed the transmural heterogeneity in myocardial integrated backscatter (THIB). "A-THIB" was defined as the absolute difference in integrated backscatter between the left (subendocardial) and right (subepicardial) ventricular halves of the myocardium in the septum and posterior wall, and was measured in 11 patients with PSS and 10 age- and sex-matched healthy participants. A-THIB in patients with PSS was higher than that in healthy participants (1.3 ± 1.3 vs 4.0 ± 1.4 dB for the septum and 1.1 ± 0.7 dB vs 2.8 ± 0.4 dB for the posterior wall; mean ± SD, respectively, P <.0005). Septal A-THIB was higher in patients with PSS with than without anti-Scl70 or antinucleolar antibodies (3.2 ± 1.1 vs 5.0 ± 1.0 dB, P = .0165). Early changes in the myocardium of patients with PSS, possibly related to increased interstitial collagen deposition, can be detected by quantitative analysis of THIB.

AB - Cardiac involvement in progressive systemic sclerosis (PSS) is common and has a strong negative impact on the prognosis, especially when autoantibodies are present. To determine whether ultrasonic tissue characterization can detect early ultrastructural changes in the sclerodermal myocardium, we analyzed the transmural heterogeneity in myocardial integrated backscatter (THIB). "A-THIB" was defined as the absolute difference in integrated backscatter between the left (subendocardial) and right (subepicardial) ventricular halves of the myocardium in the septum and posterior wall, and was measured in 11 patients with PSS and 10 age- and sex-matched healthy participants. A-THIB in patients with PSS was higher than that in healthy participants (1.3 ± 1.3 vs 4.0 ± 1.4 dB for the septum and 1.1 ± 0.7 dB vs 2.8 ± 0.4 dB for the posterior wall; mean ± SD, respectively, P <.0005). Septal A-THIB was higher in patients with PSS with than without anti-Scl70 or antinucleolar antibodies (3.2 ± 1.1 vs 5.0 ± 1.0 dB, P = .0165). Early changes in the myocardium of patients with PSS, possibly related to increased interstitial collagen deposition, can be detected by quantitative analysis of THIB.

UR - http://www.scopus.com/inward/record.url?scp=0037385286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037385286&partnerID=8YFLogxK

U2 - 10.1016/S0894-7317(02)74427-1

DO - 10.1016/S0894-7317(02)74427-1

M3 - Article

C2 - 12712016

AN - SCOPUS:0037385286

VL - 16

SP - 340

EP - 346

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

SN - 0894-7317

IS - 4

ER -