TY - JOUR
T1 - Analysis of thirteen trinucleotide repeat loci as candidate genes for schizophrenia and bipolar affective disorder
AU - Jain, Sanjeev
AU - Leggo, Jayne
AU - DeLisi, Lynne E.
AU - Crow, Timothy J.
AU - Margolis, Russell L.
AU - Li, Shi Hua
AU - Goodburn, Sandy
AU - Walsh, Cathy
AU - Paykel, Eugene S.
AU - Ferguson-Smith, Malcolm A.
AU - Ross, Christopher A.
AU - Rubinsztein, David C.
PY - 1996
Y1 - 1996
N2 - A group of diseases are due to abnormal expansions of trinucleotide repeats. These diseases all affect the nervous system. In addition, they manifest the phenomenon of anticipation, in which the disease tends to present at an earlier age or with greater severity in successive generations. Many additional genes with trinucleotide repeats are believed to be expressed in the human brain. As anticipation has been reported in schizophrenia and bipolar affective disorder, we have examined allele distributions of 13 trinucleotide repeat-containing genes, many novel and all expressed in the brain, in genomic DNA from schizophrenic (n = 20-97) and bipolar affective disorder patients (23-30) and controls (n = 43-146). No evidence was obtained to implicate expanded alleles in these 13 genes as causal factors in these diseases.
AB - A group of diseases are due to abnormal expansions of trinucleotide repeats. These diseases all affect the nervous system. In addition, they manifest the phenomenon of anticipation, in which the disease tends to present at an earlier age or with greater severity in successive generations. Many additional genes with trinucleotide repeats are believed to be expressed in the human brain. As anticipation has been reported in schizophrenia and bipolar affective disorder, we have examined allele distributions of 13 trinucleotide repeat-containing genes, many novel and all expressed in the brain, in genomic DNA from schizophrenic (n = 20-97) and bipolar affective disorder patients (23-30) and controls (n = 43-146). No evidence was obtained to implicate expanded alleles in these 13 genes as causal factors in these diseases.
KW - Bipolar affective disorder
KW - Schizophrenia
KW - Trinucleotide repeats
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U2 - 10.1002/(SICI)1096-8628(19960409)67:2<139::AID-AJMG3>3.0.CO;2-N
DO - 10.1002/(SICI)1096-8628(19960409)67:2<139::AID-AJMG3>3.0.CO;2-N
M3 - Article
C2 - 8723040
AN - SCOPUS:0029865576
SN - 0148-7299
VL - 67
SP - 139
EP - 146
JO - American Journal of Medical Genetics - Seminars in Medical Genetics
JF - American Journal of Medical Genetics - Seminars in Medical Genetics
IS - 2
ER -