Analysis of thirteen trinucleotide repeat loci as candidate genes for schizophrenia and bipolar affective disorder

Sanjeev Jain, Jayne Leggo, Lynne E. DeLisi, Timothy J. Crow, Russell L. Margolis, Shi Hua Li, Sandy Goodburn, Cathy Walsh, Eugene S. Paykel, Malcolm A. Ferguson-Smith, Christopher A. Ross, David C. Rubinsztein

Research output: Contribution to journalArticlepeer-review

Abstract

A group of diseases are due to abnormal expansions of trinucleotide repeats. These diseases all affect the nervous system. In addition, they manifest the phenomenon of anticipation, in which the disease tends to present at an earlier age or with greater severity in successive generations. Many additional genes with trinucleotide repeats are believed to be expressed in the human brain. As anticipation has been reported in schizophrenia and bipolar affective disorder, we have examined allele distributions of 13 trinucleotide repeat-containing genes, many novel and all expressed in the brain, in genomic DNA from schizophrenic (n = 20-97) and bipolar affective disorder patients (23-30) and controls (n = 43-146). No evidence was obtained to implicate expanded alleles in these 13 genes as causal factors in these diseases.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalAmerican Journal of Medical Genetics - Seminars in Medical Genetics
Volume67
Issue number2
DOIs
StatePublished - 1996

Keywords

  • Bipolar affective disorder
  • Schizophrenia
  • Trinucleotide repeats

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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