ANALYSIS OF THE RESPONSE OF THE SINO-ATRIAL NODE TO FLUCTUATIONS IN SYMPATHETIC AND PARASYMPATHETIC TONE USING BROAD BAND STIMULATION TECHNIQUES.

Ronald D. Berger, Richard J. Cohen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Frequency-domain characterizations were determined of the sino-atrial (SA) node heart-rate response to fluctuations in sympathetic and parasympathetic activity in anesthetized dogs. Either the right vagus or cardiac sympathetic nerve was stimulated with a train of supramaximal current pulses whose frequency was modulated by a bandlimited white-noise signal. Transfer functions between nerve stimulation rate and the resulting SA node firing rate were then computed using spectral techniques. It was found that the SA node response characteristics depended significantly on the mean level of vagal or sympathetic tone imposed. The experimental and analysis techniques used are broadly applicable to the investigation of all aspects of autonomic regulation.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
PublisherIEEE
Pages153-156
Number of pages4
ISBN (Print)081860817X
StatePublished - Dec 1 1987
Externally publishedYes

Publication series

NameComputers in Cardiology
ISSN (Print)0276-6574

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ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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