Analysis of the prostatic central zone in patients with unilateral absence of wolffian duct structures

further evidence of the mesodermal origin of the prostatic central zone

Research output: Contribution to journalArticle

Abstract

Purpose: We evaluate the status of the prostatic central zone in patients with unilateral absence of the seminal vesicles and vas deferens. Materials and Methods: The entire bases of the prostate specimens from 3 patients with unilateral absence of the seminal vesicles and vas deferens who underwent radical prostatectomy for prostatic adenocarcinoma were evaluated on hemotoxylin and eosin stained sections for the distribution of the central zone. Immunohistochemical stains for pepsinogen II were performed on areas thought to be central zone and on corresponding contralateral sections. Results: In 1 patient who appeared to have complete unilateral absence of wolffian duct structures the central zone was absent on that side. In the 2 other patients who did not have complete wolffian duct absence the central zone was present on the side lacking the seminal vesicle and vas deferens. The ejaculatory duct was absent on the side ipsilateral to the absent seminal vesicle and vas deferens in the 2 patients for whom it could be evaluated. Conclusions: The findings support the concept that the prostatic central zone is mesodermally derived. However, not all patients lacking the seminal vesicle and vas deferens are missing a prostatic central zone, suggesting that this is a heterogeneous disorder.

Original languageEnglish (US)
Pages (from-to)2126-2129
Number of pages4
JournalJournal of Urology
Volume160
Issue number6 I
StatePublished - 1998

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Wolffian Ducts
Vas Deferens
Seminal Vesicles
Ejaculatory Ducts
Pepsinogen C
Hematoxylin
Eosine Yellowish-(YS)
Prostatectomy
Prostate
Adenocarcinoma
Coloring Agents

Keywords

  • Mesoderm
  • Prostate
  • Wolffian duct

ASJC Scopus subject areas

  • Urology

Cite this

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title = "Analysis of the prostatic central zone in patients with unilateral absence of wolffian duct structures: further evidence of the mesodermal origin of the prostatic central zone",
abstract = "Purpose: We evaluate the status of the prostatic central zone in patients with unilateral absence of the seminal vesicles and vas deferens. Materials and Methods: The entire bases of the prostate specimens from 3 patients with unilateral absence of the seminal vesicles and vas deferens who underwent radical prostatectomy for prostatic adenocarcinoma were evaluated on hemotoxylin and eosin stained sections for the distribution of the central zone. Immunohistochemical stains for pepsinogen II were performed on areas thought to be central zone and on corresponding contralateral sections. Results: In 1 patient who appeared to have complete unilateral absence of wolffian duct structures the central zone was absent on that side. In the 2 other patients who did not have complete wolffian duct absence the central zone was present on the side lacking the seminal vesicle and vas deferens. The ejaculatory duct was absent on the side ipsilateral to the absent seminal vesicle and vas deferens in the 2 patients for whom it could be evaluated. Conclusions: The findings support the concept that the prostatic central zone is mesodermally derived. However, not all patients lacking the seminal vesicle and vas deferens are missing a prostatic central zone, suggesting that this is a heterogeneous disorder.",
keywords = "Mesoderm, Prostate, Wolffian duct",
author = "Pedram Argani",
year = "1998",
language = "English (US)",
volume = "160",
pages = "2126--2129",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "6 I",

}

TY - JOUR

T1 - Analysis of the prostatic central zone in patients with unilateral absence of wolffian duct structures

T2 - further evidence of the mesodermal origin of the prostatic central zone

AU - Argani, Pedram

PY - 1998

Y1 - 1998

N2 - Purpose: We evaluate the status of the prostatic central zone in patients with unilateral absence of the seminal vesicles and vas deferens. Materials and Methods: The entire bases of the prostate specimens from 3 patients with unilateral absence of the seminal vesicles and vas deferens who underwent radical prostatectomy for prostatic adenocarcinoma were evaluated on hemotoxylin and eosin stained sections for the distribution of the central zone. Immunohistochemical stains for pepsinogen II were performed on areas thought to be central zone and on corresponding contralateral sections. Results: In 1 patient who appeared to have complete unilateral absence of wolffian duct structures the central zone was absent on that side. In the 2 other patients who did not have complete wolffian duct absence the central zone was present on the side lacking the seminal vesicle and vas deferens. The ejaculatory duct was absent on the side ipsilateral to the absent seminal vesicle and vas deferens in the 2 patients for whom it could be evaluated. Conclusions: The findings support the concept that the prostatic central zone is mesodermally derived. However, not all patients lacking the seminal vesicle and vas deferens are missing a prostatic central zone, suggesting that this is a heterogeneous disorder.

AB - Purpose: We evaluate the status of the prostatic central zone in patients with unilateral absence of the seminal vesicles and vas deferens. Materials and Methods: The entire bases of the prostate specimens from 3 patients with unilateral absence of the seminal vesicles and vas deferens who underwent radical prostatectomy for prostatic adenocarcinoma were evaluated on hemotoxylin and eosin stained sections for the distribution of the central zone. Immunohistochemical stains for pepsinogen II were performed on areas thought to be central zone and on corresponding contralateral sections. Results: In 1 patient who appeared to have complete unilateral absence of wolffian duct structures the central zone was absent on that side. In the 2 other patients who did not have complete wolffian duct absence the central zone was present on the side lacking the seminal vesicle and vas deferens. The ejaculatory duct was absent on the side ipsilateral to the absent seminal vesicle and vas deferens in the 2 patients for whom it could be evaluated. Conclusions: The findings support the concept that the prostatic central zone is mesodermally derived. However, not all patients lacking the seminal vesicle and vas deferens are missing a prostatic central zone, suggesting that this is a heterogeneous disorder.

KW - Mesoderm

KW - Prostate

KW - Wolffian duct

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