Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

Lavanya H. Palavalli; Todd D. Prickett; John R. Wunderlich; Xiaomu Wei; Allison S. Burrell; Patricia Porter-Gill; Sean Davis; Chenwei Wang; Julia C. Cronin; Neena S. Agrawal; Jimmy C. Lin; Wendy Westbroek; Shelley Hoogstraten-Miller; Alfredo A. Molinolo; Patricia Fetsch; Armando C. Filie; Michael P. O'Connell; Carolyn E. Banister; Jason D. Howard; Phillip Buckhaults; Ashani T. Weeraratna; Lawrence C. Brody; Steven A. Rosenberg; Yardena Samuels

doi:10.1038/ng.340

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

Lavanya H. Palavalli, Todd D. Prickett, John R. Wunderlich, Xiaomu Wei, Allison S. Burrell, Patricia Porter-Gill, Sean Davis, Chenwei Wang, Julia C. Cronin, Neena S. Agrawal, Jimmy C. Lin, Wendy Westbroek, Shelley Hoogstraten-Miller, Alfredo A. Molinolo, Patricia Fetsch, Armando C. Filie, Michael P. O'Connell, Carolyn E. Banister, Jason D. Howard, Phillip BuckhaultsAshani T. Weeraratna, Lawrence C. Brody, Steven A. Rosenberg, Yardena Samuels

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression.

Original language	English (US)
Pages (from-to)	518-520
Number of pages	3
Journal	Nature genetics
Volume	41
Issue number	5
DOIs	https://doi.org/10.1038/ng.340
State	Published - May 2009

ASJC Scopus subject areas

Genetics

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Palavalli, L. H., Prickett, T. D., Wunderlich, J. R., Wei, X., Burrell, A. S., Porter-Gill, P., Davis, S., Wang, C., Cronin, J. C., Agrawal, N. S., Lin, J. C., Westbroek, W., Hoogstraten-Miller, S., Molinolo, A. A., Fetsch, P., Filie, A. C., O'Connell, M. P., Banister, C. E., Howard, J. D., ... Samuels, Y. (2009). Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. Nature genetics, 41(5), 518-520. https://doi.org/10.1038/ng.340

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. / Palavalli, Lavanya H.; Prickett, Todd D.; Wunderlich, John R.; Wei, Xiaomu; Burrell, Allison S.; Porter-Gill, Patricia; Davis, Sean; Wang, Chenwei; Cronin, Julia C.; Agrawal, Neena S.; Lin, Jimmy C.; Westbroek, Wendy; Hoogstraten-Miller, Shelley; Molinolo, Alfredo A.; Fetsch, Patricia; Filie, Armando C.; O'Connell, Michael P.; Banister, Carolyn E.; Howard, Jason D.; Buckhaults, Phillip; Weeraratna, Ashani T.; Brody, Lawrence C.; Rosenberg, Steven A.; Samuels, Yardena.

In: Nature genetics, Vol. 41, No. 5, 05.2009, p. 518-520.

Research output: Contribution to journal › Article › peer-review

Palavalli, LH, Prickett, TD, Wunderlich, JR, Wei, X, Burrell, AS, Porter-Gill, P, Davis, S, Wang, C, Cronin, JC, Agrawal, NS, Lin, JC, Westbroek, W, Hoogstraten-Miller, S, Molinolo, AA, Fetsch, P, Filie, AC, O'Connell, MP, Banister, CE, Howard, JD, Buckhaults, P, Weeraratna, AT, Brody, LC, Rosenberg, SA & Samuels, Y 2009, 'Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma', Nature genetics, vol. 41, no. 5, pp. 518-520. https://doi.org/10.1038/ng.340

Palavalli, Lavanya H. ; Prickett, Todd D. ; Wunderlich, John R. ; Wei, Xiaomu ; Burrell, Allison S. ; Porter-Gill, Patricia ; Davis, Sean ; Wang, Chenwei ; Cronin, Julia C. ; Agrawal, Neena S. ; Lin, Jimmy C. ; Westbroek, Wendy ; Hoogstraten-Miller, Shelley ; Molinolo, Alfredo A. ; Fetsch, Patricia ; Filie, Armando C. ; O'Connell, Michael P. ; Banister, Carolyn E. ; Howard, Jason D. ; Buckhaults, Phillip ; Weeraratna, Ashani T. ; Brody, Lawrence C. ; Rosenberg, Steven A. ; Samuels, Yardena. / Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. In: Nature genetics. 2009 ; Vol. 41, No. 5. pp. 518-520.

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title = "Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma",

abstract = "A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression.",

author = "Palavalli, {Lavanya H.} and Prickett, {Todd D.} and Wunderlich, {John R.} and Xiaomu Wei and Burrell, {Allison S.} and Patricia Porter-Gill and Sean Davis and Chenwei Wang and Cronin, {Julia C.} and Agrawal, {Neena S.} and Lin, {Jimmy C.} and Wendy Westbroek and Shelley Hoogstraten-Miller and Molinolo, {Alfredo A.} and Patricia Fetsch and Filie, {Armando C.} and O'Connell, {Michael P.} and Banister, {Carolyn E.} and Howard, {Jason D.} and Phillip Buckhaults and Weeraratna, {Ashani T.} and Brody, {Lawrence C.} and Rosenberg, {Steven A.} and Yardena Samuels",

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Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

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