Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

Lavanya H. Palavalli, Todd D. Prickett, John R. Wunderlich, Xiaomu Wei, Allison S. Burrell, Patricia Porter-Gill, Sean Davis, Chenwei Wang, Julia C. Cronin, Neena S. Agrawal, Jimmy C. Lin, Wendy Westbroek, Shelley Hoogstraten-Miller, Alfredo A. Molinolo, Patricia Fetsch, Armando C. Filie, Michael P. O'Connell, Carolyn E. Banister, Jason D. Howard, Phillip BuckhaultsAshani T. Weeraratna, Lawrence C. Brody, Steven A. Rosenberg, Yardena Samuels

Research output: Contribution to journalArticlepeer-review

Abstract

A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression.

Original languageEnglish (US)
Pages (from-to)518-520
Number of pages3
JournalNature genetics
Volume41
Issue number5
DOIs
StatePublished - May 2009

ASJC Scopus subject areas

  • Genetics

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