Analysis of the human type I insulin-like growth factor receptor promoter region

David W. Cooke, Laura A. Bankert, Charles T. Roberts, Derek LeRoith, Samuel J. Casella

Research output: Contribution to journalArticle

Abstract

We isolated genomic fragments containing the 5′ region of the human type I insulin-like growth factor receptor gene. A unique transcription start site was identified, defining a 1038 bp 5′-untranslated region. No TATA or CCAAT elements were identified in the proximal 480 nucleotides of 5′-flanking region. The region surrounding the transcription start site was similar to a recently described "initiator" sequence. The 5′-flanking and 5′-untranslated regions were highly GC-rich, with numerous potential Sp1 binding sites. A potential AP-2 binding site was identified in the 5′-flanking region and a potential thyroid response element was identified in the 5′-untranslated region. The 5′ region of the human gene was very similar to that of the rat gene, with conservation of many of the potential regulatory elements.

Original languageEnglish (US)
Pages (from-to)1113-1120
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume177
Issue number3
DOIs
StatePublished - Jun 28 1991

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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