Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

Xiaomu Wei, Angela Moncada-Pazos, Santiago Cal, Clara Soria-Valles, Jared Gartner, Udo Rudloff, Jimmy C. Lin, Steven A. Rosenberg, Carlos López-Otín, Yardena Samuels

Research output: Contribution to journalComment/debate

Abstract

We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression.

Original languageEnglish (US)
Pages (from-to)E2148-E2175
JournalHuman mutation
Volume32
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • ADAM29
  • ADAM7
  • Melanoma
  • Somatic mutation

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma'. Together they form a unique fingerprint.

  • Cite this

    Wei, X., Moncada-Pazos, A., Cal, S., Soria-Valles, C., Gartner, J., Rudloff, U., Lin, J. C., Rosenberg, S. A., López-Otín, C., & Samuels, Y. (2011). Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. Human mutation, 32(6), E2148-E2175. https://doi.org/10.1002/humu.21477