Analysis of the clinical problems in parkinsonism and the complications of long-term levodopa therapy

Ronald P Lesser, Stanley Fahn, Stuart R. Snider, Lucien J. Cote, William P. Isgreen, Robert E. Barrett

Research output: Contribution to journalArticle

Abstract

We evaluated the current status of 131 patients with idiopathic parkinsonism who were receiving levodopa therapy. The residual parkinsonian symptoms and signs were tabulated, as were the adverse effects from medication. Response to therapy was correlated with duration of the disease and with duration of treatment. Patients with on-off or wearing-off effects were likely to have been treated for 4 years or longer. Patients treated with levodopa for 4 to 8 years were significantly more impaired with parkinsonism than patients treated for 0 to 3 years, even when patients were matched for total duration of disease. These data suggest that the deterioration of responsiveness after several years of levodopa therapy may be due to the therapy itself. Our findings support the concept that utilization of levodopa therapy should be delayed until a patient becomes significantly impaired in occupational or social situations.

Original languageEnglish (US)
Pages (from-to)1253-1260
Number of pages8
JournalNeurology
Volume29
Issue number9
StatePublished - 1979
Externally publishedYes

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Parkinsonian Disorders
Levodopa
Therapeutics
Signs and Symptoms
Therapy
Complications

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Lesser, R. P., Fahn, S., Snider, S. R., Cote, L. J., Isgreen, W. P., & Barrett, R. E. (1979). Analysis of the clinical problems in parkinsonism and the complications of long-term levodopa therapy. Neurology, 29(9), 1253-1260.

Analysis of the clinical problems in parkinsonism and the complications of long-term levodopa therapy. / Lesser, Ronald P; Fahn, Stanley; Snider, Stuart R.; Cote, Lucien J.; Isgreen, William P.; Barrett, Robert E.

In: Neurology, Vol. 29, No. 9, 1979, p. 1253-1260.

Research output: Contribution to journalArticle

Lesser, RP, Fahn, S, Snider, SR, Cote, LJ, Isgreen, WP & Barrett, RE 1979, 'Analysis of the clinical problems in parkinsonism and the complications of long-term levodopa therapy', Neurology, vol. 29, no. 9, pp. 1253-1260.
Lesser, Ronald P ; Fahn, Stanley ; Snider, Stuart R. ; Cote, Lucien J. ; Isgreen, William P. ; Barrett, Robert E. / Analysis of the clinical problems in parkinsonism and the complications of long-term levodopa therapy. In: Neurology. 1979 ; Vol. 29, No. 9. pp. 1253-1260.
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