Analysis of Statistical Biases inStudies Used to Formulate Guidelines. The Case of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) The Case of ARVC

Tessa S. Cook, Stefan Zimmerman, Saurabh Jha

Research output: Contribution to journalArticle

Abstract

Rationale and Objectives: To analyze the statistical biases in the studies used to derive cardiac magnetic resonance-based major and minor criteria for the diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC). Materials and Methods: ARVC is a rare disorder of the heart that can lead to sudden death in young adults. Cardiac magnetic resonance imaging (CMR) plays a role in the diagnosis by contributing to the criteria set by experts. The original criteria emphasized qualitative analysis of CMR. The criteria were modified in 2010 to provide quantitative cutoffs. Results: We apply the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool for systematic review of diagnostic accuracy to the studies cited in the guidelines written in 1994 and revised in 2010. We use the signaling questions in QUADAS-2 to identify different types of statistical bias. Conclusions: The studies have understandable biases that affect the sensitivity and specificity of CMR in the diagnosis of ARVC, as well as the truth of the disease state. There is potential to overdiagnose ARVC particularly in low prevalence populations.

Original languageEnglish (US)
Pages (from-to)1010-1015
Number of pages6
JournalAcademic Radiology
Volume22
Issue number8
DOIs
StatePublished - Aug 1 2015

Fingerprint

Arrhythmogenic Right Ventricular Dysplasia
Guidelines
Magnetic Resonance Imaging
Sudden Death
Young Adult
Magnetic Resonance Spectroscopy
Sensitivity and Specificity
Population

Keywords

  • Arrhythmogenic right ventricular cardiomyopathy
  • Bias
  • Overdiagnosis
  • QUADAS-2

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Analysis of Statistical Biases inStudies Used to Formulate Guidelines. The Case of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) The Case of ARVC. / Cook, Tessa S.; Zimmerman, Stefan; Jha, Saurabh.

In: Academic Radiology, Vol. 22, No. 8, 01.08.2015, p. 1010-1015.

Research output: Contribution to journalArticle

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