TY - JOUR
T1 - Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials
AU - Serebruany, Victor L.
AU - Steinhubl, Steven R.
AU - Berger, Peter B.
AU - Malinin, Alex I.
AU - Baggish, Jeffrey S.
AU - Bhatt, Deepak L.
AU - Topol, Eric J.
PY - 2005/5/15
Y1 - 2005/5/15
N2 - We sought to compare the risk of hemorrhage due to the low (200 mg) doses of aspirin (acetylsalicylic acid [ASA]) in 192,036 patients enrolled in 31 clinical trials. Despite substantial differences in the reporting patterns of bleeding complications, low-dose ASA was associated with the lowest risk, and moderate doses caused a relatively high hemorrhagic event rate, especially with regard to minor, gastrointestinal, and total bleeding, and stroke. These findings should be considered when using combination antiplatelets, anticoagulant therapy, or both, with ASA, especially with the daily dose of >100 mg.
AB - We sought to compare the risk of hemorrhage due to the low (200 mg) doses of aspirin (acetylsalicylic acid [ASA]) in 192,036 patients enrolled in 31 clinical trials. Despite substantial differences in the reporting patterns of bleeding complications, low-dose ASA was associated with the lowest risk, and moderate doses caused a relatively high hemorrhagic event rate, especially with regard to minor, gastrointestinal, and total bleeding, and stroke. These findings should be considered when using combination antiplatelets, anticoagulant therapy, or both, with ASA, especially with the daily dose of >100 mg.
UR - http://www.scopus.com/inward/record.url?scp=18144373789&partnerID=8YFLogxK
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U2 - 10.1016/j.amjcard.2005.01.049
DO - 10.1016/j.amjcard.2005.01.049
M3 - Article
C2 - 15877994
AN - SCOPUS:18144373789
SN - 0002-9149
VL - 95
SP - 1218
EP - 1222
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 10
ER -