Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials

Victor L. Serebruany, Steven R. Steinhubl, Peter B. Berger, Alex I. Malinin, Jeffrey S. Baggish, Deepak L. Bhatt, Eric J. Topol

Research output: Contribution to journalArticle

Abstract

We sought to compare the risk of hemorrhage due to the low (200 mg) doses of aspirin (acetylsalicylic acid [ASA]) in 192,036 patients enrolled in 31 clinical trials. Despite substantial differences in the reporting patterns of bleeding complications, low-dose ASA was associated with the lowest risk, and moderate doses caused a relatively high hemorrhagic event rate, especially with regard to minor, gastrointestinal, and total bleeding, and stroke. These findings should be considered when using combination antiplatelets, anticoagulant therapy, or both, with ASA, especially with the daily dose of >100 mg.

Original languageEnglish (US)
Pages (from-to)1218-1222
Number of pages5
JournalThe American Journal of Cardiology
Volume95
Issue number10
DOIs
Publication statusPublished - May 15 2005
Externally publishedYes

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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