Analysis of mechanical feedback to the central respiratory pattern generator

Kurt A.E. Geitz, Allan Gottschalk

Research output: Contribution to journalConference articlepeer-review

Abstract

Analyzing the role of sensory feedback to the central respiratory pattern generator (CRPG) in modulating the pattern of respiration is difficult because of the complexity and uncertainty of the underlying systems. To overcome this difficulty we apply an analytic approach which focuses on the essential features of the CRPG without the need to specify the precise mechanism of rhythm generation. The limit cycle behavior of the isolated CRPG allows a general model of the closed system to be simplified to one that depends on the amplitude of respiration and the phase difference between the CRPG and the lungs. This simplification does not require the use of any unmeasurable parameters or unproven hypotheses. Using this analytic approach we can explicitly obtain the entire experimentally determined relationship between respiratory volume and period, and demonstrate that this relies upon the existence of a nonlinear threshold to mechanical feedback. Computational experiments with several different models confirm this result and its independence from the source of the limit cycle.

Original languageEnglish (US)
Pages (from-to)1031-1032
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume16
Issue numberpt 2
StatePublished - Dec 1 1994
Externally publishedYes
EventProceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 (of 2) - Baltimore, MD, USA
Duration: Nov 3 1994Nov 6 1994

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Fingerprint

Dive into the research topics of 'Analysis of mechanical feedback to the central respiratory pattern generator'. Together they form a unique fingerprint.

Cite this