Analysis of lung nodule detectability and anatomical clutter in tomosynthesis imaging of the chest

Sungwon Yoon, Jianan G. Gang, Daniel J. Tward, Jeffrey H. Siewerdsen, Rebecca Fahrig

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Scopus citations


Tomosynthesis is an imaging technique that has gained renewed interest with recent advancements of flat-panel digital detectors. Because of the wide range of potential applications, a systematic analysis of 3D tomosynthesis imaging systems would contribute to the understanding and development. This paper extends a systematic evaluation of thoracic tomosynthetic imaging performance as a function of imaging parameters, such as the number of projections, tomosynthesis orbital extent, and reconstruction filters. We evaluate lung nodule detectability and anatomical clutter as a function of tomosynthesis orbital extent using anthropomorphic phantoms and a table-top acquisition system. Tomosynthesis coronal slices were reconstructed using the FDK algorithm for cone-beam geometry from 91 projections uniformly distributed over acquisition orbital extents (θ) ranging from 10 to 180. Visual comparisons of different tomosynthesis reconstructions of a lung nodule show the progressive decrease of anatomical clutter as & thete increases. Additionally, three quantitative figures of merit were computed and compared: signal-difference-to-noise ratio (SDNR), anatomical clutter power spectrum (PS), and theoretical detectability index (DI). Lung nodule SDNR increases as θ increases from 0 to 120. Anatomical clutter PS shows that the clutter magnitude and correlation decrease as θ increases, increasing detectability. Similarly, 2D and 3D DI increase as θ increases in the anatomical dominated exposure ranges. On the other hand, 2D slice DI is lower than the 3D DI for larger θ (e.g. 120), because of the information loss in the depth direction for 2D slices. In other words, inspecting 3D is better for larger acquisition orbital extents, because the extra information acquired at larger angles cannot be fully recovered from 2D tomosynthesis reconstruction sli ces. In summary, detectability in tomosynthesis reconstructions for thoracic imaging increases as fixed dose is distributed over a larger acquisition orbital extent (up to 120).

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationPhysics of Medical Imaging
StatePublished - 2009
EventMedical Imaging 2009: Physics of Medical Imaging - Lake Buena Vista, FL, United States
Duration: Feb 9 2009Feb 12 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2009: Physics of Medical Imaging
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • Anatomical clutter
  • Anthropomorphic phantom
  • Chest imaging
  • Detectability
  • Lung nodule
  • Power spectrum
  • Tomosynthesis

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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