Analysis of individual human papillomavirus types in cervical neoplasia: A possible role for type 18 in rapid progression

Robert J Kurman, M. H. Schiffman, W. D. Lancaster, R. Reid, A. B. Jenson, G. F. Temple, A. T. Lorincz

Research output: Contribution to journalArticle

Abstract

Histologic and molecular analyses of 214 cervical biopsy specimens were performed to test the hypothesis that certain individual human papillomavirus types that are usually grouped together are differentially distributed in various grades of cervical intraepithelial neoplasia and invasive squamous carcinoma. Specifically, types 16 and 18, which are commonly grouped together, where analyzed separately and compared. Biopsies obtained from three different geographic sites in the United States and Brazil were analyzed by Southern blot hybridization and correlated with the histologic diagnosis from the same tissue sample. There was a highly significant correlation between papillomavirus type and histologic grade comparing all grades of cervical intraepithelial neoplasia with invasive cancer (p <0.001). Of particular interest was the striking deficit of type 18 in intraepithelial neoplasia (3%) as compared with invasive carcinoma (22%; p <0.001). In contrast, there was no significant difference in the distribution of type 16 in intraepithelial neoplasia (37%) as compared with invasive carcinoma (41%). The deficit of type 18 in intraepithelial neoplasia compared with invasive carcinoma could represent a rapid transit time through the precursor stage. Human papillomavirus type 18 may therefore play a role in the development of rapidly progressive cervical cancer.

Original languageEnglish (US)
Pages (from-to)293-296
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume159
Issue number2
StatePublished - 1988
Externally publishedYes

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Cervical Intraepithelial Neoplasia
Carcinoma
Neoplasms
Biopsy
Human papillomavirus 18
Southern Blotting
Uterine Cervical Neoplasms
Brazil
Squamous Cell Carcinoma

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Kurman, R. J., Schiffman, M. H., Lancaster, W. D., Reid, R., Jenson, A. B., Temple, G. F., & Lorincz, A. T. (1988). Analysis of individual human papillomavirus types in cervical neoplasia: A possible role for type 18 in rapid progression. American Journal of Obstetrics and Gynecology, 159(2), 293-296.

Analysis of individual human papillomavirus types in cervical neoplasia : A possible role for type 18 in rapid progression. / Kurman, Robert J; Schiffman, M. H.; Lancaster, W. D.; Reid, R.; Jenson, A. B.; Temple, G. F.; Lorincz, A. T.

In: American Journal of Obstetrics and Gynecology, Vol. 159, No. 2, 1988, p. 293-296.

Research output: Contribution to journalArticle

Kurman, RJ, Schiffman, MH, Lancaster, WD, Reid, R, Jenson, AB, Temple, GF & Lorincz, AT 1988, 'Analysis of individual human papillomavirus types in cervical neoplasia: A possible role for type 18 in rapid progression', American Journal of Obstetrics and Gynecology, vol. 159, no. 2, pp. 293-296.
Kurman, Robert J ; Schiffman, M. H. ; Lancaster, W. D. ; Reid, R. ; Jenson, A. B. ; Temple, G. F. ; Lorincz, A. T. / Analysis of individual human papillomavirus types in cervical neoplasia : A possible role for type 18 in rapid progression. In: American Journal of Obstetrics and Gynecology. 1988 ; Vol. 159, No. 2. pp. 293-296.
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