Analysis of immune status of hemodialyzed adults: Association with prior transfusions

B. S. Bender, J. L. Curtis, J. E. Nagel, F. J. Chrest, E. S. Kraus, G. R. Briefel, W. H. Adler

Research output: Contribution to journalArticlepeer-review

Abstract

Peripheral blood leukocytes of 29 hemodialyzed adults, 19 transfused and 10 nontransfused, were studied using immunofluorescent staining with monoclonal antibodies and in vitro measurement of natural killer (NK) cell activity. When compared with control subjects, the absolute number of leukocytes in transfused hemodialyzed patients was significantly reduced (P < 0.01), as were the absolute numbers of OKT11+ cells (P < 0.01), and OKT4+ cells (P < 0.0001). The percent representation of OKT11+ and OKT4+ cells was also significantly lower among transfused hemodialyzed patients (P < 0.01 and 0.001 respectively), and this loss of OKT4+ cells resulted in a decrease in the ratio of OKT4+/OKT8+ cells (P < 0.01). The absolute number of Leu-7+ cells was also decreased in the transfused group (P < 0.05). A decrease in in vitro NK cell activity was present in both transfused and nontransfused hemodialyzed subjects. Whether these differences in peripheral blood lymphocytes were induced by the erythrocyte transfusions could not be determined; however, if they reflect changes in central lymphoid tissues, then these results may help explain the prolonged survival of renal allografts in transfused individuals.

Original languageEnglish (US)
Pages (from-to)436-443
Number of pages8
JournalKidney international
Volume26
Issue number4
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Analysis of immune status of hemodialyzed adults: Association with prior transfusions'. Together they form a unique fingerprint.

Cite this