Analysis of HIV tropism in Ugandan infants.

Jessica D. Church, Wei Huang, Anthony Mwatha, Philippa Musoke, J. Brooks Jackson, Danstan Bagenda, Saad B. Omer, Deborah Donnell, Clemensia Nakabiito, Chineta Eure, Laura A. Guay, Allan Taylor, Paul M. Bakaki, Flavia Matovu, Michelle McConnell, Mary Glenn Fowler, Susan H. Eshleman

Research output: Contribution to journalArticle

Abstract

HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6-8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6-12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5-RLU at 6-8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).

Original languageEnglish (US)
Pages (from-to)498-503
Number of pages6
JournalCurrent HIV research
Volume8
Issue number7
StatePublished - Oct 1 2010

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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  • Cite this

    Church, J. D., Huang, W., Mwatha, A., Musoke, P., Jackson, J. B., Bagenda, D., Omer, S. B., Donnell, D., Nakabiito, C., Eure, C., Guay, L. A., Taylor, A., Bakaki, P. M., Matovu, F., McConnell, M., Fowler, M. G., & Eshleman, S. H. (2010). Analysis of HIV tropism in Ugandan infants. Current HIV research, 8(7), 498-503.