Analysis of HIV Integrase Resistance in Black Men Who Have Sex with Men in the United States

Iris Chen; Yinfeng Zhang; Vanessa Cummings; Gavin A. Cloherty; Matthew Connor; Geetha Beauchamp; Sam Griffith; Scott Rose; Joel Gallant; Hyman M. Scott; Steven Shoptaw; Carlos Del Rio; Irene Kuo; Sharon Mannheimer; Hong Van Tieu; Christopher B. Hurt; Sheldon D. Fields; Darrell P. Wheeler; Kenneth H. Mayer; Beryl A. Koblin; Susan H. Eshleman

doi:10.1089/aid.2017.0005

Analysis of HIV Integrase Resistance in Black Men Who Have Sex with Men in the United States

Iris Chen, Yinfeng Zhang, Vanessa Cummings, Gavin A. Cloherty, Matthew Connor, Geetha Beauchamp, Sam Griffith, Scott Rose, Joel Gallant, Hyman M. Scott, Steven Shoptaw, Carlos Del Rio, Irene Kuo, Sharon Mannheimer, Hong Van Tieu, Christopher B. Hurt, Sheldon D. Fields, Darrell P. Wheeler, Kenneth H. Mayer, Beryl A. KoblinSusan H. Eshleman

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Resistance to reverse transcriptase and protease inhibitors was frequently detected in HIV from black men who have sex with men (MSM) enrolled in the HIV prevention trials network (HPTN) 061 study. In this study, integrase strand transfer inhibitor (INSTI) resistance was analyzed in black MSM enrolled in HPTN 061 (134 infected at enrollment and 23 seroconverters) and a follow-up study, HPTN 073 (eight seroconverters). The ViroSeq HIV-1 Integrase Genotyping Kit (Abbott Molecular) was used for analysis. Major INSTI resistance mutations were not detected in any of the samples. HIV from 14 (8.4%) of the 165 men, including 4 (12.9%) of 31 seroconverters, had accessory or polymorphic INSTI-associated mutations. The most frequently detected mutation was E157Q. These findings are promising because INSTI-based regimens are now recommended for first-line antiretroviral treatment and because long-acting cabotegravir is being evaluated for pre-exposure prophylaxis.

Original language	English (US)
Pages (from-to)	745-748
Number of pages	4
Journal	AIDS research and human retroviruses
Volume	33
Issue number	7
DOIs	https://doi.org/10.1089/aid.2017.0005
State	Published - Jul 2017

Keywords

HIV integrase
drug resistance
integrase inhibitor
men who have sex with men

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

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10.1089/aid.2017.0005

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Chen, I., Zhang, Y., Cummings, V., Cloherty, G. A., Connor, M., Beauchamp, G., Griffith, S., Rose, S., Gallant, J., Scott, H. M., Shoptaw, S., Del Rio, C., Kuo, I., Mannheimer, S., Tieu, H. V., Hurt, C. B., Fields, S. D., Wheeler, D. P., Mayer, K. H., ... Eshleman, S. H. (2017). Analysis of HIV Integrase Resistance in Black Men Who Have Sex with Men in the United States. AIDS research and human retroviruses, 33(7), 745-748. https://doi.org/10.1089/aid.2017.0005

Chen, I, Zhang, Y, Cummings, V, Cloherty, GA, Connor, M, Beauchamp, G, Griffith, S, Rose, S, Gallant, J, Scott, HM, Shoptaw, S, Del Rio, C, Kuo, I, Mannheimer, S, Tieu, HV, Hurt, CB, Fields, SD, Wheeler, DP, Mayer, KH, Koblin, BA & Eshleman, SH 2017, 'Analysis of HIV Integrase Resistance in Black Men Who Have Sex with Men in the United States', AIDS research and human retroviruses, vol. 33, no. 7, pp. 745-748. https://doi.org/10.1089/aid.2017.0005

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title = "Analysis of HIV Integrase Resistance in Black Men Who Have Sex with Men in the United States",

abstract = "Resistance to reverse transcriptase and protease inhibitors was frequently detected in HIV from black men who have sex with men (MSM) enrolled in the HIV prevention trials network (HPTN) 061 study. In this study, integrase strand transfer inhibitor (INSTI) resistance was analyzed in black MSM enrolled in HPTN 061 (134 infected at enrollment and 23 seroconverters) and a follow-up study, HPTN 073 (eight seroconverters). The ViroSeq HIV-1 Integrase Genotyping Kit (Abbott Molecular) was used for analysis. Major INSTI resistance mutations were not detected in any of the samples. HIV from 14 (8.4%) of the 165 men, including 4 (12.9%) of 31 seroconverters, had accessory or polymorphic INSTI-associated mutations. The most frequently detected mutation was E157Q. These findings are promising because INSTI-based regimens are now recommended for first-line antiretroviral treatment and because long-acting cabotegravir is being evaluated for pre-exposure prophylaxis.",

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AU - Connor, Matthew

AU - Beauchamp, Geetha

AU - Griffith, Sam

AU - Rose, Scott

AU - Gallant, Joel

AU - Scott, Hyman M.

AU - Shoptaw, Steven

AU - Del Rio, Carlos

AU - Kuo, Irene

AU - Mannheimer, Sharon

AU - Tieu, Hong Van

AU - Hurt, Christopher B.

AU - Fields, Sheldon D.

AU - Wheeler, Darrell P.

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AU - Eshleman, Susan H.

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N2 - Resistance to reverse transcriptase and protease inhibitors was frequently detected in HIV from black men who have sex with men (MSM) enrolled in the HIV prevention trials network (HPTN) 061 study. In this study, integrase strand transfer inhibitor (INSTI) resistance was analyzed in black MSM enrolled in HPTN 061 (134 infected at enrollment and 23 seroconverters) and a follow-up study, HPTN 073 (eight seroconverters). The ViroSeq HIV-1 Integrase Genotyping Kit (Abbott Molecular) was used for analysis. Major INSTI resistance mutations were not detected in any of the samples. HIV from 14 (8.4%) of the 165 men, including 4 (12.9%) of 31 seroconverters, had accessory or polymorphic INSTI-associated mutations. The most frequently detected mutation was E157Q. These findings are promising because INSTI-based regimens are now recommended for first-line antiretroviral treatment and because long-acting cabotegravir is being evaluated for pre-exposure prophylaxis.

AB - Resistance to reverse transcriptase and protease inhibitors was frequently detected in HIV from black men who have sex with men (MSM) enrolled in the HIV prevention trials network (HPTN) 061 study. In this study, integrase strand transfer inhibitor (INSTI) resistance was analyzed in black MSM enrolled in HPTN 061 (134 infected at enrollment and 23 seroconverters) and a follow-up study, HPTN 073 (eight seroconverters). The ViroSeq HIV-1 Integrase Genotyping Kit (Abbott Molecular) was used for analysis. Major INSTI resistance mutations were not detected in any of the samples. HIV from 14 (8.4%) of the 165 men, including 4 (12.9%) of 31 seroconverters, had accessory or polymorphic INSTI-associated mutations. The most frequently detected mutation was E157Q. These findings are promising because INSTI-based regimens are now recommended for first-line antiretroviral treatment and because long-acting cabotegravir is being evaluated for pre-exposure prophylaxis.

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Analysis of HIV Integrase Resistance in Black Men Who Have Sex with Men in the United States

Abstract

Keywords

ASJC Scopus subject areas

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