Analysis of HIV Integrase Resistance in Black Men Who Have Sex with Men in the United States

Iris Chen, Yinfeng Zhang, Vanessa Cummings, Gavin A. Cloherty, Matthew Connor, Geetha Beauchamp, Sam Griffith, Scott Rose, Joel Gallant, Hyman M. Scott, Steven Shoptaw, Carlos Del Rio, Irene Kuo, Sharon Mannheimer, Hong Van Tieu, Christopher B. Hurt, Sheldon D. Fields, Darrell P. Wheeler, Kenneth H. Mayer, Beryl A. Koblin & 1 others Susan Eshleman

Research output: Contribution to journalArticle

Abstract

Resistance to reverse transcriptase and protease inhibitors was frequently detected in HIV from black men who have sex with men (MSM) enrolled in the HIV prevention trials network (HPTN) 061 study. In this study, integrase strand transfer inhibitor (INSTI) resistance was analyzed in black MSM enrolled in HPTN 061 (134 infected at enrollment and 23 seroconverters) and a follow-up study, HPTN 073 (eight seroconverters). The ViroSeq HIV-1 Integrase Genotyping Kit (Abbott Molecular) was used for analysis. Major INSTI resistance mutations were not detected in any of the samples. HIV from 14 (8.4%) of the 165 men, including 4 (12.9%) of 31 seroconverters, had accessory or polymorphic INSTI-associated mutations. The most frequently detected mutation was E157Q. These findings are promising because INSTI-based regimens are now recommended for first-line antiretroviral treatment and because long-acting cabotegravir is being evaluated for pre-exposure prophylaxis.

Original languageEnglish (US)
Pages (from-to)745-748
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume33
Issue number7
DOIs
StatePublished - Jul 1 2017

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HIV Integrase
Integrases
HIV
Mutation
Reverse Transcriptase Inhibitors
Protease Inhibitors

Keywords

  • drug resistance
  • HIV integrase
  • integrase inhibitor
  • men who have sex with men

ASJC Scopus subject areas

  • Immunology
  • Infectious Diseases
  • Virology

Cite this

Analysis of HIV Integrase Resistance in Black Men Who Have Sex with Men in the United States. / Chen, Iris; Zhang, Yinfeng; Cummings, Vanessa; Cloherty, Gavin A.; Connor, Matthew; Beauchamp, Geetha; Griffith, Sam; Rose, Scott; Gallant, Joel; Scott, Hyman M.; Shoptaw, Steven; Del Rio, Carlos; Kuo, Irene; Mannheimer, Sharon; Tieu, Hong Van; Hurt, Christopher B.; Fields, Sheldon D.; Wheeler, Darrell P.; Mayer, Kenneth H.; Koblin, Beryl A.; Eshleman, Susan.

In: AIDS Research and Human Retroviruses, Vol. 33, No. 7, 01.07.2017, p. 745-748.

Research output: Contribution to journalArticle

Chen, I, Zhang, Y, Cummings, V, Cloherty, GA, Connor, M, Beauchamp, G, Griffith, S, Rose, S, Gallant, J, Scott, HM, Shoptaw, S, Del Rio, C, Kuo, I, Mannheimer, S, Tieu, HV, Hurt, CB, Fields, SD, Wheeler, DP, Mayer, KH, Koblin, BA & Eshleman, S 2017, 'Analysis of HIV Integrase Resistance in Black Men Who Have Sex with Men in the United States', AIDS Research and Human Retroviruses, vol. 33, no. 7, pp. 745-748. https://doi.org/10.1089/aid.2017.0005
Chen, Iris ; Zhang, Yinfeng ; Cummings, Vanessa ; Cloherty, Gavin A. ; Connor, Matthew ; Beauchamp, Geetha ; Griffith, Sam ; Rose, Scott ; Gallant, Joel ; Scott, Hyman M. ; Shoptaw, Steven ; Del Rio, Carlos ; Kuo, Irene ; Mannheimer, Sharon ; Tieu, Hong Van ; Hurt, Christopher B. ; Fields, Sheldon D. ; Wheeler, Darrell P. ; Mayer, Kenneth H. ; Koblin, Beryl A. ; Eshleman, Susan. / Analysis of HIV Integrase Resistance in Black Men Who Have Sex with Men in the United States. In: AIDS Research and Human Retroviruses. 2017 ; Vol. 33, No. 7. pp. 745-748.
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