Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays

Laurie Ward Whitney, Kevin G. Becker, Nancy J. Tresser, Carla I. Caballero-Ramos, Peter J. Munson, Vinayakumar V. Prabhu, Jeffrey M. Trent, Henry F. McFarland, William E. Biddison

Research output: Contribution to journalArticlepeer-review

Abstract

In multiple sclerosis (MS) patients, a coordinated attack of the immune system against the primary constituents of oligodendrocytes and/or the myelin sheath of oligodendrocytes results in the formation of lesions in the brain and spinal cord. Thus far, however, a limited number of genes that potentially contribute to lesion pathology have been identified. Using cDNA microarray technology, we have performed experiments on MS tissue monitoring the expression pattern of over 5,000 genes and compared the gene expression profile of normal white matter with that found in acute lesions from the brain of a single MS patient. Sixty-two differentially expressed genes were identified, including the Duffy chemokine receptor, interferon regulatory factor-2, and tumor necrosis factor alpha receptor-2 among others. Thus, cDNA microarray technology represents a powerful new tool for the identification of genes not previously associated with the MS disease process.

Original languageEnglish (US)
Pages (from-to)425-428
Number of pages4
JournalAnnals of neurology
Volume46
Issue number3
DOIs
StatePublished - Sep 13 1999

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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