TY - JOUR
T1 - Analysis of exhaled breath for disease detection
AU - Amann, Anton
AU - Miekisch, Wolfram
AU - Schubert, Jochen
AU - Buszewski, Bogusław
AU - Ligor, Tomasz
AU - Jezierski, Tadeusz
AU - Pleil, Joachim
AU - Risby, Terence
PY - 2014/6
Y1 - 2014/6
N2 - Breath analysis is a young field of research with great clinical potential. As a result of this interest, researchers have developed new analytical techniques that permit real-time analysis of exhaled breath with breath-to-breath resolution in addition to the conventional central laboratory methods using gas chromatography-mass spectrometry. Breath tests are based on endogenously produced volatiles, metabolites of ingested precursors, metabolites produced by bacteria in the gut or the airways, or volatiles appearing after environmental exposure. The composition of exhaled breath may contain valuable information for patients presenting with asthma, renal and liver diseases, lung cancer, chronic obstructive pulmonary disease, inflammatory lung disease, or metabolic disorders. In addition, oxidative stress status may be monitored via volatile products of lipid peroxidation. Measurement of enzyme activity provides phenotypic information important in personalized medicine, whereas breath measurements provide insight into perturbations of the human exposome and can be interpreted as preclinical signals of adverse outcome pathways. ©
AB - Breath analysis is a young field of research with great clinical potential. As a result of this interest, researchers have developed new analytical techniques that permit real-time analysis of exhaled breath with breath-to-breath resolution in addition to the conventional central laboratory methods using gas chromatography-mass spectrometry. Breath tests are based on endogenously produced volatiles, metabolites of ingested precursors, metabolites produced by bacteria in the gut or the airways, or volatiles appearing after environmental exposure. The composition of exhaled breath may contain valuable information for patients presenting with asthma, renal and liver diseases, lung cancer, chronic obstructive pulmonary disease, inflammatory lung disease, or metabolic disorders. In addition, oxidative stress status may be monitored via volatile products of lipid peroxidation. Measurement of enzyme activity provides phenotypic information important in personalized medicine, whereas breath measurements provide insight into perturbations of the human exposome and can be interpreted as preclinical signals of adverse outcome pathways. ©
KW - Environmental health
KW - Gas chromatography
KW - Human exposome
KW - Ion mobility spectrometry
KW - Laser spectrometry
KW - Personalized medicine
KW - Preclinical effects
KW - Proton-transfer-reaction time-of-flight mass spectrometry
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U2 - 10.1146/annurev-anchem-071213-020043
DO - 10.1146/annurev-anchem-071213-020043
M3 - Review article
C2 - 25014347
AN - SCOPUS:84904338175
SN - 1936-1327
VL - 7
SP - 455
EP - 482
JO - Annual Review of Analytical Chemistry
JF - Annual Review of Analytical Chemistry
ER -