Analysis of exhaled breath for disease detection

Anton Amann, Wolfram Miekisch, Jochen Schubert, Bogusław Buszewski, Tomasz Ligor, Tadeusz Jezierski, Joachim Pleil, Terence H Risby

Research output: Contribution to journalArticle

Abstract

Breath analysis is a young field of research with great clinical potential. As a result of this interest, researchers have developed new analytical techniques that permit real-time analysis of exhaled breath with breath-to-breath resolution in addition to the conventional central laboratory methods using gas chromatography-mass spectrometry. Breath tests are based on endogenously produced volatiles, metabolites of ingested precursors, metabolites produced by bacteria in the gut or the airways, or volatiles appearing after environmental exposure. The composition of exhaled breath may contain valuable information for patients presenting with asthma, renal and liver diseases, lung cancer, chronic obstructive pulmonary disease, inflammatory lung disease, or metabolic disorders. In addition, oxidative stress status may be monitored via volatile products of lipid peroxidation. Measurement of enzyme activity provides phenotypic information important in personalized medicine, whereas breath measurements provide insight into perturbations of the human exposome and can be interpreted as preclinical signals of adverse outcome pathways. ©

Original languageEnglish (US)
Pages (from-to)455-482
Number of pages28
JournalAnnual Review of Analytical Chemistry
Volume7
DOIs
StatePublished - 2014

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Pulmonary diseases
Metabolites
Oxidative stress
Enzyme activity
Gas chromatography
Liver
Medicine
Mass spectrometry
Bacteria
Lipids
Chemical analysis

Keywords

  • Environmental health
  • Gas chromatography
  • Human exposome
  • Ion mobility spectrometry
  • Laser spectrometry
  • Personalized medicine
  • Preclinical effects
  • Proton-transfer-reaction time-of-flight mass spectrometry

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Analysis of exhaled breath for disease detection. / Amann, Anton; Miekisch, Wolfram; Schubert, Jochen; Buszewski, Bogusław; Ligor, Tomasz; Jezierski, Tadeusz; Pleil, Joachim; Risby, Terence H.

In: Annual Review of Analytical Chemistry, Vol. 7, 2014, p. 455-482.

Research output: Contribution to journalArticle

Amann, A, Miekisch, W, Schubert, J, Buszewski, B, Ligor, T, Jezierski, T, Pleil, J & Risby, TH 2014, 'Analysis of exhaled breath for disease detection', Annual Review of Analytical Chemistry, vol. 7, pp. 455-482. https://doi.org/10.1146/annurev-anchem-071213-020043
Amann A, Miekisch W, Schubert J, Buszewski B, Ligor T, Jezierski T et al. Analysis of exhaled breath for disease detection. Annual Review of Analytical Chemistry. 2014;7:455-482. https://doi.org/10.1146/annurev-anchem-071213-020043
Amann, Anton ; Miekisch, Wolfram ; Schubert, Jochen ; Buszewski, Bogusław ; Ligor, Tomasz ; Jezierski, Tadeusz ; Pleil, Joachim ; Risby, Terence H. / Analysis of exhaled breath for disease detection. In: Annual Review of Analytical Chemistry. 2014 ; Vol. 7. pp. 455-482.
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