Analysis of epitope information related to Bacillus anthracis and Clostridium botulinum

Laura M. Zarebski, Kerrie Vaughan, John Sidney, Bjoern Peters, Howard Grey, Kim D. Janda, Arturo Casadevall, Alessandro Sette

Research output: Contribution to journalReview articlepeer-review

Abstract

We have reviewed the information about epitopes of immunological interest from Clostridium botulinum and Bacillus anthracis, by mining the Immune Epitope Database and Analysis Resource. For both pathogens, the vast majority of epitopes reported to date are derived from a single protein: the protective antigen of B. anthracis and the neurotoxin type A of C. botulinum. A detailed analysis of the data was performed to characterize the function, localization and conservancy of epitopes identified as neutralizing and/or protective. In order to broaden the scope of this analysis, we have also included data describing immune responses against defined fragments (over 50 amino acids long) of the relevant antigens. The scarce information on T-cell determinants and on epitopes from other antigens besides the toxins, highlights a gap in our knowledge and identifies areas for future research. Despite this, several distinct structures at the epitope and fragment level are described herein, which could be potential additions to future vaccines or targets of novel immunotherapeutics and diagnostic reagents.

Original languageEnglish (US)
Pages (from-to)55-74
Number of pages20
JournalExpert review of vaccines
Volume7
Issue number1
DOIs
StatePublished - Feb 2008
Externally publishedYes

Keywords

  • Anthrax toxin
  • Bacillus anthracis
  • Botulinum toxin
  • Clostridium botulinum
  • Epitope
  • Therapeutic antibodies
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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