Analysis of component findings in 79 patients diagnosed with VACTERL association

Benjamin D. Solomon, Daniel E. Pineda-Alvarez, Manu S. Raam, Sophia M. Bous, Amelia A. Keaton, Jorge I. Vélez, Derek A T Cummings

Research output: Contribution to journalArticlepeer-review

Abstract

VACTERL association is a relatively common condition, though the causes remain poorly understood. We present data on 79 patients diagnosed with VACTERL association and perform statistical analysis on a selected subset of 60 patients with at least three component features, and who, after review, did not meet criteria for a likely alternate diagnosis. Considered individually, no two component features are significantly associated, but several multivariate statistical techniques suggest novel patterns of the co-occurrence of component features, and latent class cluster analysis demonstrates the presence of five major sub-groups of patients. These findings have implications for both our understanding of VACTERL association and for the approach to research involving this condition. Published 2010 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)2236-2244
Number of pages9
JournalAmerican Journal of Medical Genetics, Part A
Volume152
Issue number9
DOIs
StatePublished - Sep 2010

Keywords

  • VACTERL
  • VACTERL association
  • VATER
  • VATER association

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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