TY - JOUR
T1 - Analysis of combined drug effects
T2 - a new look at a very old problem
AU - Chou, Ting Chao
AU - Talalay, Paul
N1 - Funding Information:
Acknowledgements The authors receive research support from the National Institutes of Health (AM 07422 and CA 27569) and from the American Cancer Society (SIG-3).
PY - 1983
Y1 - 1983
N2 - A simple, general and novel method for the quantitative analysis of combined drug effects is presented. The procedure determines if the drug combinations are additive, synergistic or antagonistic, regardless of whether the dose-effect curves are hyperbolic (first order) or sigmoidal (higher order), or whether the effects of the drugs are totally independent or not. We believe that the proposed method (median-effect plot) suffers from fewer restrictions and is more widely applicable than the isobologram or the fractional product method. It provides insight into the nature of the dose-effect relationship with relatively few measurements. We illustrate the procedure by analysing the combined lethal effects of two insecticides on house-flies.
AB - A simple, general and novel method for the quantitative analysis of combined drug effects is presented. The procedure determines if the drug combinations are additive, synergistic or antagonistic, regardless of whether the dose-effect curves are hyperbolic (first order) or sigmoidal (higher order), or whether the effects of the drugs are totally independent or not. We believe that the proposed method (median-effect plot) suffers from fewer restrictions and is more widely applicable than the isobologram or the fractional product method. It provides insight into the nature of the dose-effect relationship with relatively few measurements. We illustrate the procedure by analysing the combined lethal effects of two insecticides on house-flies.
UR - http://www.scopus.com/inward/record.url?scp=0000994406&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0000994406&partnerID=8YFLogxK
U2 - 10.1016/0165-6147(83)90490-X
DO - 10.1016/0165-6147(83)90490-X
M3 - Article
AN - SCOPUS:0000994406
VL - 4
SP - 450
EP - 454
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
SN - 0165-6147
IS - C
ER -