Abstract
Objective: To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events. Methods: Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011–2012 and analyzed. Results: Multivariate logistic regression analysis showed positive associations between TD and BMI (≥35 vs. < 18.5: OR = 2.51, 95% CI: 1.19–5.32, p = .016), HDL-c (<0.91 vs. ≥0.91: OR = 1.60, 95% CI: 1.14–2.24, p = .006) and diabetes (diabetes vs. non-diabetes: OR = 1.48, 95% CI: 1.14–1.92, p = .004) as well as negative associations between TD and metabolic equivalent scores (≥12 vs. <12: OR = 0.69, 95% CI: 0.52–0.91, p = .009) and smoking (Ever vs. never: OR = 0.69, 95% CI: 0.51–0.94, p = .018). Furthermore, total serum testosterone levels were lower in patients with heart failure (p = .04) and angina/angina pectoris (p = .001) compared with subjects without these cardiac problems. Conclusion: Low serum testosterone was associated with multiple risk factors for CHD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Aging Male |
| DOIs | |
| State | Accepted/In press - Jun 20 2018 |
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Keywords
- BMI
- cardiovascular disease
- CHD
- HDL-c
- NHANES
- testosterone deficiency
ASJC Scopus subject areas
- Geriatrics and Gerontology
Cite this
Analysis of cardiovascular risk factors associated with serum testosterone levels according to the US 2011–2012 National Health and Nutrition Examination Survey. / Deng, Chunhua; Zhang, Zhichao; Li, Hongjun; Bai, Peng; Cao, Xian; Dobs, Adrian S.
In: Aging Male, 20.06.2018, p. 1-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of cardiovascular risk factors associated with serum testosterone levels according to the US 2011–2012 National Health and Nutrition Examination Survey
AU - Deng, Chunhua
AU - Zhang, Zhichao
AU - Li, Hongjun
AU - Bai, Peng
AU - Cao, Xian
AU - Dobs, Adrian S
PY - 2018/6/20
Y1 - 2018/6/20
N2 - Objective: To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events. Methods: Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011–2012 and analyzed. Results: Multivariate logistic regression analysis showed positive associations between TD and BMI (≥35 vs. < 18.5: OR = 2.51, 95% CI: 1.19–5.32, p = .016), HDL-c (<0.91 vs. ≥0.91: OR = 1.60, 95% CI: 1.14–2.24, p = .006) and diabetes (diabetes vs. non-diabetes: OR = 1.48, 95% CI: 1.14–1.92, p = .004) as well as negative associations between TD and metabolic equivalent scores (≥12 vs. <12: OR = 0.69, 95% CI: 0.52–0.91, p = .009) and smoking (Ever vs. never: OR = 0.69, 95% CI: 0.51–0.94, p = .018). Furthermore, total serum testosterone levels were lower in patients with heart failure (p = .04) and angina/angina pectoris (p = .001) compared with subjects without these cardiac problems. Conclusion: Low serum testosterone was associated with multiple risk factors for CHD.
AB - Objective: To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events. Methods: Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011–2012 and analyzed. Results: Multivariate logistic regression analysis showed positive associations between TD and BMI (≥35 vs. < 18.5: OR = 2.51, 95% CI: 1.19–5.32, p = .016), HDL-c (<0.91 vs. ≥0.91: OR = 1.60, 95% CI: 1.14–2.24, p = .006) and diabetes (diabetes vs. non-diabetes: OR = 1.48, 95% CI: 1.14–1.92, p = .004) as well as negative associations between TD and metabolic equivalent scores (≥12 vs. <12: OR = 0.69, 95% CI: 0.52–0.91, p = .009) and smoking (Ever vs. never: OR = 0.69, 95% CI: 0.51–0.94, p = .018). Furthermore, total serum testosterone levels were lower in patients with heart failure (p = .04) and angina/angina pectoris (p = .001) compared with subjects without these cardiac problems. Conclusion: Low serum testosterone was associated with multiple risk factors for CHD.
KW - BMI
KW - cardiovascular disease
KW - CHD
KW - HDL-c
KW - NHANES
KW - testosterone deficiency
UR - http://www.scopus.com/inward/record.url?scp=85048738853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048738853&partnerID=8YFLogxK
U2 - 10.1080/13685538.2018.1479387
DO - 10.1080/13685538.2018.1479387
M3 - Article
C2 - 29925274
AN - SCOPUS:85048738853
SP - 1
EP - 8
JO - Aging Male
JF - Aging Male
SN - 1368-5538
ER -