TY - JOUR
T1 - Analysis of cardiovascular risk factors associated with serum testosterone levels according to the US 2011–2012 National Health and Nutrition Examination Survey
AU - Deng, Chunhua
AU - Zhang, Zhichao
AU - Li, Hongjun
AU - Bai, Peng
AU - Cao, Xian
AU - Dobs, Adrian Sandra
N1 - Funding Information:
This study was supported by funding from Merck Sharp & Dohme (MSD; Whitehouse Station, NJ, USA). Editorial assistance was provided by Dr. Endler of Shanghai BIOMED Science Technology (Shanghai, China) through funding provided by MSD China.
PY - 2019/4/3
Y1 - 2019/4/3
N2 - Objective: To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events. Methods: Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011–2012 and analyzed. Results: Multivariate logistic regression analysis showed positive associations between TD and BMI (≥35 vs. < 18.5: OR = 2.51, 95% CI: 1.19–5.32, p =.016), HDL-c (<0.91 vs. ≥0.91: OR = 1.60, 95% CI: 1.14–2.24, p =.006) and diabetes (diabetes vs. non-diabetes: OR = 1.48, 95% CI: 1.14–1.92, p =.004) as well as negative associations between TD and metabolic equivalent scores (≥12 vs. <12: OR = 0.69, 95% CI: 0.52–0.91, p =.009) and smoking (Ever vs. never: OR = 0.69, 95% CI: 0.51–0.94, p =.018). Furthermore, total serum testosterone levels were lower in patients with heart failure (p =.04) and angina/angina pectoris (p =.001) compared with subjects without these cardiac problems. Conclusion: Low serum testosterone was associated with multiple risk factors for CHD.
AB - Objective: To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events. Methods: Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011–2012 and analyzed. Results: Multivariate logistic regression analysis showed positive associations between TD and BMI (≥35 vs. < 18.5: OR = 2.51, 95% CI: 1.19–5.32, p =.016), HDL-c (<0.91 vs. ≥0.91: OR = 1.60, 95% CI: 1.14–2.24, p =.006) and diabetes (diabetes vs. non-diabetes: OR = 1.48, 95% CI: 1.14–1.92, p =.004) as well as negative associations between TD and metabolic equivalent scores (≥12 vs. <12: OR = 0.69, 95% CI: 0.52–0.91, p =.009) and smoking (Ever vs. never: OR = 0.69, 95% CI: 0.51–0.94, p =.018). Furthermore, total serum testosterone levels were lower in patients with heart failure (p =.04) and angina/angina pectoris (p =.001) compared with subjects without these cardiac problems. Conclusion: Low serum testosterone was associated with multiple risk factors for CHD.
KW - BMI
KW - CHD
KW - HDL-c
KW - NHANES
KW - cardiovascular disease
KW - testosterone deficiency
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U2 - 10.1080/13685538.2018.1479387
DO - 10.1080/13685538.2018.1479387
M3 - Article
C2 - 29925274
AN - SCOPUS:85048738853
VL - 22
SP - 121
EP - 128
JO - Aging Male
JF - Aging Male
SN - 1368-5538
IS - 2
ER -