Analysis of cardiovascular risk factors associated with serum testosterone levels according to the US 2011–2012 National Health and Nutrition Examination Survey

Chunhua Deng, Zhichao Zhang, Hongjun Li, Peng Bai, Xian Cao, Adrian S Dobs

Research output: Contribution to journalArticle

Abstract

Objective: To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events. Methods: Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011–2012 and analyzed. Results: Multivariate logistic regression analysis showed positive associations between TD and BMI (≥35 vs. < 18.5: OR = 2.51, 95% CI: 1.19–5.32, p = .016), HDL-c (<0.91 vs. ≥0.91: OR = 1.60, 95% CI: 1.14–2.24, p = .006) and diabetes (diabetes vs. non-diabetes: OR = 1.48, 95% CI: 1.14–1.92, p = .004) as well as negative associations between TD and metabolic equivalent scores (≥12 vs. <12: OR = 0.69, 95% CI: 0.52–0.91, p = .009) and smoking (Ever vs. never: OR = 0.69, 95% CI: 0.51–0.94, p = .018). Furthermore, total serum testosterone levels were lower in patients with heart failure (p = .04) and angina/angina pectoris (p = .001) compared with subjects without these cardiac problems. Conclusion: Low serum testosterone was associated with multiple risk factors for CHD.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalAging Male
DOIs
StateAccepted/In press - Jun 20 2018

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Nutrition Surveys
Testosterone
Serum
HDL Cholesterol
Body Mass Index
Smoking
Metabolic Equivalent
C-Peptide
Angina Pectoris
Homocysteine
C-Reactive Protein
Fasting
Creatinine
Cardiovascular Diseases
Phosphotransferases
Heart Failure
Logistic Models
Cholesterol
Regression Analysis
Alcohols

Keywords

  • BMI
  • cardiovascular disease
  • CHD
  • HDL-c
  • NHANES
  • testosterone deficiency

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Analysis of cardiovascular risk factors associated with serum testosterone levels according to the US 2011–2012 National Health and Nutrition Examination Survey. / Deng, Chunhua; Zhang, Zhichao; Li, Hongjun; Bai, Peng; Cao, Xian; Dobs, Adrian S.

In: Aging Male, 20.06.2018, p. 1-8.

Research output: Contribution to journalArticle

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abstract = "Objective: To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events. Methods: Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011–2012 and analyzed. Results: Multivariate logistic regression analysis showed positive associations between TD and BMI (≥35 vs. < 18.5: OR = 2.51, 95{\%} CI: 1.19–5.32, p = .016), HDL-c (<0.91 vs. ≥0.91: OR = 1.60, 95{\%} CI: 1.14–2.24, p = .006) and diabetes (diabetes vs. non-diabetes: OR = 1.48, 95{\%} CI: 1.14–1.92, p = .004) as well as negative associations between TD and metabolic equivalent scores (≥12 vs. <12: OR = 0.69, 95{\%} CI: 0.52–0.91, p = .009) and smoking (Ever vs. never: OR = 0.69, 95{\%} CI: 0.51–0.94, p = .018). Furthermore, total serum testosterone levels were lower in patients with heart failure (p = .04) and angina/angina pectoris (p = .001) compared with subjects without these cardiac problems. Conclusion: Low serum testosterone was associated with multiple risk factors for CHD.",
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AU - Bai, Peng

AU - Cao, Xian

AU - Dobs, Adrian S

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AB - Objective: To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events. Methods: Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011–2012 and analyzed. Results: Multivariate logistic regression analysis showed positive associations between TD and BMI (≥35 vs. < 18.5: OR = 2.51, 95% CI: 1.19–5.32, p = .016), HDL-c (<0.91 vs. ≥0.91: OR = 1.60, 95% CI: 1.14–2.24, p = .006) and diabetes (diabetes vs. non-diabetes: OR = 1.48, 95% CI: 1.14–1.92, p = .004) as well as negative associations between TD and metabolic equivalent scores (≥12 vs. <12: OR = 0.69, 95% CI: 0.52–0.91, p = .009) and smoking (Ever vs. never: OR = 0.69, 95% CI: 0.51–0.94, p = .018). Furthermore, total serum testosterone levels were lower in patients with heart failure (p = .04) and angina/angina pectoris (p = .001) compared with subjects without these cardiac problems. Conclusion: Low serum testosterone was associated with multiple risk factors for CHD.

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KW - HDL-c

KW - NHANES

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