TY - JOUR
T1 - Analysis of cardiovascular risk factors associated with serum testosterone levels according to the US 2011–2012 National Health and Nutrition Examination Survey
AU - Deng, Chunhua
AU - Zhang, Zhichao
AU - Li, Hongjun
AU - Bai, Peng
AU - Cao, Xian
AU - Dobs, Adrian Sandra
N1 - Funding Information:
This study was supported by funding from Merck Sharp & Dohme (MSD; Whitehouse Station, NJ, USA). Editorial assistance was provided by Dr. Endler of Shanghai BIOMED Science Technology (Shanghai, China) through funding provided by MSD China.
Funding Information:
This study was supported by funding from Merck Sharp & Dohme (MSD; Whitehouse Station, NJ, USA). Editorial assistance was provided by Dr. Endler of Shanghai BIOMED Science Technology (Shanghai, China) through funding provided by MSD China. The authors were solely responsible for the conception and performance of this study and the writing of this manuscript.
Publisher Copyright:
© 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/4/3
Y1 - 2019/4/3
N2 - Objective: To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events. Methods: Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011–2012 and analyzed. Results: Multivariate logistic regression analysis showed positive associations between TD and BMI (≥35 vs. < 18.5: OR = 2.51, 95% CI: 1.19–5.32, p =.016), HDL-c (<0.91 vs. ≥0.91: OR = 1.60, 95% CI: 1.14–2.24, p =.006) and diabetes (diabetes vs. non-diabetes: OR = 1.48, 95% CI: 1.14–1.92, p =.004) as well as negative associations between TD and metabolic equivalent scores (≥12 vs. <12: OR = 0.69, 95% CI: 0.52–0.91, p =.009) and smoking (Ever vs. never: OR = 0.69, 95% CI: 0.51–0.94, p =.018). Furthermore, total serum testosterone levels were lower in patients with heart failure (p =.04) and angina/angina pectoris (p =.001) compared with subjects without these cardiac problems. Conclusion: Low serum testosterone was associated with multiple risk factors for CHD.
AB - Objective: To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events. Methods: Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011–2012 and analyzed. Results: Multivariate logistic regression analysis showed positive associations between TD and BMI (≥35 vs. < 18.5: OR = 2.51, 95% CI: 1.19–5.32, p =.016), HDL-c (<0.91 vs. ≥0.91: OR = 1.60, 95% CI: 1.14–2.24, p =.006) and diabetes (diabetes vs. non-diabetes: OR = 1.48, 95% CI: 1.14–1.92, p =.004) as well as negative associations between TD and metabolic equivalent scores (≥12 vs. <12: OR = 0.69, 95% CI: 0.52–0.91, p =.009) and smoking (Ever vs. never: OR = 0.69, 95% CI: 0.51–0.94, p =.018). Furthermore, total serum testosterone levels were lower in patients with heart failure (p =.04) and angina/angina pectoris (p =.001) compared with subjects without these cardiac problems. Conclusion: Low serum testosterone was associated with multiple risk factors for CHD.
KW - BMI
KW - CHD
KW - HDL-c
KW - NHANES
KW - cardiovascular disease
KW - testosterone deficiency
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U2 - 10.1080/13685538.2018.1479387
DO - 10.1080/13685538.2018.1479387
M3 - Article
C2 - 29925274
AN - SCOPUS:85048738853
SN - 1368-5538
VL - 22
SP - 121
EP - 128
JO - Aging Male
JF - Aging Male
IS - 2
ER -