Analysis of Busulfan in Plasma by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Abed Pablo; Autumn R. Breaud; William Clarke

doi:10.1002/cptx.93

Analysis of Busulfan in Plasma by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Abed Pablo, Autumn R. Breaud, William Clarke

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Bone marrow transplantation is used to treat particular types of cancers such as lymphoma, leukemia, and multiple myeloma. Appropriate dosing of busulfan during the preparative phase is critical for a successful allograft; if blood concentrations get too high significant liver toxicity can occur, if blood concentrations are too low, then graft-versus-host disease (GVHD) can develop. Busulfan monitoring in blood allows hospitals with the opportunity to provide individualized medicine to patients and improve overall patient outcome. Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is an important analytical method for quantification of busulfan in plasma in order to optimize the dose.

Original language	English (US)
Article number	e93
Journal	Current Protocols in Toxicology
Volume	84
Issue number	1
DOIs	https://doi.org/10.1002/cptx.93
State	Published - Jun 1 2020

Keywords

bone marrow transplantation
busulfan
chromatography
tandem mass spectrometry
therapeutic drug monitoring

ASJC Scopus subject areas

Toxicology

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10.1002/cptx.93

Cite this

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AB - Bone marrow transplantation is used to treat particular types of cancers such as lymphoma, leukemia, and multiple myeloma. Appropriate dosing of busulfan during the preparative phase is critical for a successful allograft; if blood concentrations get too high significant liver toxicity can occur, if blood concentrations are too low, then graft-versus-host disease (GVHD) can develop. Busulfan monitoring in blood allows hospitals with the opportunity to provide individualized medicine to patients and improve overall patient outcome. Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is an important analytical method for quantification of busulfan in plasma in order to optimize the dose.

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Analysis of Busulfan in Plasma by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Abstract

Keywords

ASJC Scopus subject areas

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