Abstract
Bone marrow transplantation is used to treat particular types of cancers such as lymphoma, leukemia, and multiple myeloma. Appropriate dosing of busulfan during the preparative phase is critical for a successful allograft; if blood concentrations get too high significant liver toxicity can occur, if blood concentrations are too low, then graft-versus-host disease (GVHD) can develop. Busulfan monitoring in blood allows hospitals with the opportunity to provide individualized medicine to patients and improve overall patient outcome. Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is an important analytical method for quantification of busulfan in plasma in order to optimize the dose.
Original language | English (US) |
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Article number | e93 |
Journal | Current Protocols in Toxicology |
Volume | 84 |
Issue number | 1 |
DOIs | |
State | Published - Jun 1 2020 |
Keywords
- bone marrow transplantation
- busulfan
- chromatography
- tandem mass spectrometry
- therapeutic drug monitoring
ASJC Scopus subject areas
- Toxicology