Abstract
Bone marrow transplantation is used to treat particular types of cancers such as lymphoma, leukemia, and multiple myeloma. Appropriate dosing of busulfan during the preparative phase is critical for a successful allograft; if blood concentrations get too high significant liver toxicity can occur, if blood concentrations are too low, then graft-versus-host disease (GVHD) can develop. Busulfan monitoring in blood allows hospitals with the opportunity to provide individualized medicine to patients and improve overall patient outcome. Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is an important analytical method for quantification of busulfan in plasma in order to optimize the dose.
| Original language | English (US) |
|---|---|
| Article number | e93 |
| Journal | Current Protocols in Toxicology |
| Volume | 84 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jun 1 2020 |
Keywords
- bone marrow transplantation
- busulfan
- chromatography
- tandem mass spectrometry
- therapeutic drug monitoring
ASJC Scopus subject areas
- Toxicology
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Pablo, A., Breaud, A. R., & Clarke, W. (2020). Analysis of Busulfan in Plasma by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Current Protocols in Toxicology, 84(1), [e93]. https://doi.org/10.1002/cptx.93