Analysis of association between gene polymorphisms of microsomal epoxido hydrolase (EPHX1) and infant birthweight

Di Wu, Xiu Qing Zhang, Fan Yang, Xiumei Hong, Fei Ju, Da Fang Chen

Research output: Contribution to journalArticle

Abstract

We investigated association between genetic polymorphisms of EPHX1 in mother and infant birthweight. Data of 342 female workers were collected in textile mill. A total of 342 mothers were genotyped for the His 139 Arg polymorphism of EPHX1 by a polymerase chain reaction-restriction fragment length polymorphism assay. Using multiple linear regression models, we estimated the adjusted association between polymorphisms of EPHX1 and birthweight, with adjusted for potential confounders. We found that polymorphisms of EPHX1 were closely associated with reduced birthweight (β ± SE= - 149g ± 56, P = 0.0083) after adjustment for major cofounders. In subgroup of passive smoking analysis, the polymorphisms of EPHX1 were highly associted with birthweight for those with passive smoking (β ± SE = - 234g ± 88, P = 0.0088); The significant association of EPHX1 polymorphisms with reduced birthweight were showed for those with working stress (β ± SE = - 157g ± 59, P = 0.0079). Our data provide polymorphisms of EPHX1 in mothers were significant association with birthweight of their infant, and showed gene-enviromental interaction in relation to birthweight.

Original languageEnglish (US)
Pages (from-to)599-600
Number of pages2
JournalActa Genetica Sinica
Volume28
Issue number7
StatePublished - 2001
Externally publishedYes

Fingerprint

Hydrolases
Tobacco Smoke Pollution
Mothers
Linear Models
Genes
Textiles
Genetic Polymorphisms
Restriction Fragment Length Polymorphisms
Polymerase Chain Reaction

Keywords

  • Birthweight
  • Cigarette smoking
  • Microsomal epoxide hydrolase
  • Polymorphisms
  • Stress

ASJC Scopus subject areas

  • Genetics

Cite this

Analysis of association between gene polymorphisms of microsomal epoxido hydrolase (EPHX1) and infant birthweight. / Wu, Di; Zhang, Xiu Qing; Yang, Fan; Hong, Xiumei; Ju, Fei; Chen, Da Fang.

In: Acta Genetica Sinica, Vol. 28, No. 7, 2001, p. 599-600.

Research output: Contribution to journalArticle

Wu, Di ; Zhang, Xiu Qing ; Yang, Fan ; Hong, Xiumei ; Ju, Fei ; Chen, Da Fang. / Analysis of association between gene polymorphisms of microsomal epoxido hydrolase (EPHX1) and infant birthweight. In: Acta Genetica Sinica. 2001 ; Vol. 28, No. 7. pp. 599-600.
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AU - Chen, Da Fang

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