Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2

Kristen L. Deak, Margaret E. Dickerson, Elwood Linney, David S. Enterline, Timothy M. George, Elizabeth C. Melvin, Felicia L. Graham, Deborah G. Siegel, Preston Hammock, Lorraine Mehltretter, Alexander G. Bassuk, John A. Kessler, John R. Gilbert, Marcy C. Speer, Joanna Aben, Arthur Aylsworth, Cynthia Powell, Joanne Mackey, Gordon Worley, Timothy BreiConnie Buran, Joann Bodurtha, Kathleen Sawin, Mark S. Dias, Philip Mack, Elli Meeropol, Nicole Lasarsky, David McLone, Joy Ito, W. Jerry Oakes, Marion Walker, Paxila Peterson, Bermans Iskandar

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Vitamin A (retinol), in the form of retinoic acid (RA), is essential for normal development of the human embryo. Studies in the mouse and zebrafish have shown that retinol is metabolized in the developing spinal cord and must be maintained in a precise balance along the anteroposterior axis. Both excess and deficiency of RA can affect morphogenesis, including failures of neural tube closure. METHODS: We chose to investigate 5 genes involved in the metabolism or synthesis of RA, ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP1, for their role in the development of human neural tube defects, such as spina bifida. RESULTS: An association analysis using both allelic and genotypic single-locus tests revealed a significant association between the risk for spina bifida and 3 polymorphisms in the gene ALDH1A2; however, we found no evidence of a significant multilocus association. CONCLUSIONS: These results may suggest that polymorphisms in ALDH1A2 may influence the risk for lumbosacral myelomeningocele in humans.

Original languageEnglish (US)
Pages (from-to)868-875
Number of pages8
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Volume73
Issue number11
DOIs
StatePublished - Nov 1 2005
Externally publishedYes

Keywords

  • ALDH1A2
  • CRABP1
  • CRABP2
  • CYP26A1
  • CYP26B1
  • Neural tube defects
  • Retinoic acid

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Developmental Biology

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    Deak, K. L., Dickerson, M. E., Linney, E., Enterline, D. S., George, T. M., Melvin, E. C., Graham, F. L., Siegel, D. G., Hammock, P., Mehltretter, L., Bassuk, A. G., Kessler, J. A., Gilbert, J. R., Speer, M. C., Aben, J., Aylsworth, A., Powell, C., Mackey, J., Worley, G., ... Iskandar, B. (2005). Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. Birth Defects Research Part A - Clinical and Molecular Teratology, 73(11), 868-875. https://doi.org/10.1002/bdra.20183