Analysis of a polytef granuloma mimicking a cold thyroid nodule 17 months after laryngeal injection

Fred Sanfilippo, John Sheiburne, Peter Ingram

Research output: Contribution to journalArticle


A 65-year-old female who received laryngeal injections with polytef (Teflon) paste for treatment of right vocal cord paralysis first noticed a small, right anterior neck mass 17 months later. Clinically this mass slowly progressed in size and was felt to be a recurrent carotid body tumor, but at surgery, 22 months after injection, a circumscribed nodule on the anterior right lobe of the thyroid was found and histologically diag-nosed as a foreign body granuloma. Scanning electron microscopy (SEM) and energy-dispersive x-ray analysis (EDXA) of material in this lesion was identical to that of polytef paste, which is a mixture of pyrolyzed poly-tetrafluoroethylene and glycerine. The possibility that deaggregated smaller particles in the polytef paste were able to migrate from the injection site resulting in this neck mass is considered.

Original languageEnglish (US)
Pages (from-to)471-475
Number of pages5
JournalUltrastructural Pathology
Issue number4
Publication statusPublished - 1980
Externally publishedYes



  • Energy-dispersive x-ray analysis (EDXA)
  • Fluorine
  • Granuloma
  • Polytef
  • Thyroid nodule

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology
  • Instrumentation

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