ANALGESIC EFFICACY OF PARENTERAL METKEPHAMID ACETATE IN TREATMENT OF POSTOPERATIVE PAIN

J. F. Calimlim, K. Sriwatanakul, William M. Wardell, L. Lasagna, C. Cox

Research output: Contribution to journalArticle

Abstract

The analgesic efficacy and side-effects of a single parenteral dose of metkephamid acetate 70 mg were compared with those of pethidine (meperidine) hydrochloride 100 mg and placebo in a double-blind, randomised, controlled clinical trial. 30 out of 32 postoperative patients completed the study-10 in the metkephamid group, 11 in the pethidine group, and 9 in the placebo group. The time-effect curves of summated pain measures and analyses of derived measures all indicated that the analgesic activity of metkephamid 70 mg was significantly greater than that of placebo and not less than that of pethidine 100 mg. The metkephamid group had a greater incidence of side-effects than the other two treatment groups. Some side-effects, such as sensations of heaviness of the extremities and nasal congestion, were peculiar to metkephamid but not distressing.

Original languageEnglish (US)
Pages (from-to)1374-1375
Number of pages2
JournalThe Lancet
Volume319
Issue number8286
DOIs
StatePublished - Jun 19 1982
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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