TY - JOUR
T1 - AAAPT Diagnostic Criteria for Acute Sickle Cell Disease Pain
AU - Field, Joshua J.
AU - Ballas, Samir K.
AU - Campbell, Claudia M.
AU - Crosby, Lori E.
AU - Dampier, Carlton
AU - Darbari, Deepika S.
AU - McClish, Donna K.
AU - Smith, Wally R.
AU - Zempsky, William T.
N1 - Funding Information:
Disclosures: JJF has been a consultant for Ironwood and receives research funding from Ironwood, Prolong, and Incyte. SKB, CMC, LEC have no disclosures. CD has research funding from Pfizer, Sancilio, Novartis, and Katz Foundation; he is a consultant for Pfizer, Novartis, Global Blood Therapeutics, Epizyme, Ironwood, Prolong Therapeutics; he is on the advisory board for Pfizer, Novartis, and Sancilio. DSD; DSD is on the advisory board of Hilton Publishing, DKM, WRM have no disclosures. WTZ is a consultant GlasxoSmithKline, Pfizer, and endo pharmaceuticals.
Funding Information:
Support was provided by the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks public–private Partnership with the U.S. Food and Drug Administration (FDA), which has received contracts, grants, and other revenue for its activities with the FDA, multiple pharmaceutical and device companies, and other sources. A complete list of the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks sponsors is available at: http://www.acttion.org/partners. No official endorsement by the FDA should be inferred. PiSCES was funded by the National Heart, Lung, and Blood Institute.
Funding Information:
Support was provided by the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks public?private Partnership with the U.S. Food and Drug Administration (FDA), which has received contracts, grants, and other revenue for its activities with the FDA, multiple pharmaceutical and device companies, and other sources. A complete list of the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks sponsors is available at: http://www.acttion.org/partners. No official endorsement by the FDA should be inferred. PiSCES was funded by the National Heart, Lung, and Blood Institute. Disclosures: JJF has been a consultant for Ironwood and receives research funding from Ironwood, Prolong, and Incyte. SKB, CMC, LEC have no disclosures. CD has research funding from Pfizer, Sancilio, Novartis, and Katz Foundation; he is a consultant for Pfizer, Novartis, Global Blood Therapeutics, Epizyme, Ironwood, Prolong Therapeutics; he is on the advisory board for Pfizer, Novartis, and Sancilio. DSD; DSD is on the advisory board of Hilton Publishing, DKM, WRM have no disclosures. WTZ is a consultant GlasxoSmithKline, Pfizer, and endo pharmaceuticals.
Publisher Copyright:
© 2018 the American Pain Society
PY - 2019/7
Y1 - 2019/7
N2 - Acute pain episodes are the most common complication in patients with sickle cell disease (SCD). Classically attributed to vaso-occlusion, recent insights suggest that chronic pain may also contribute to the pathogenesis of acute pain episodes, which adds complexity to their diagnosis and management. A taxonomy, or classification system, for acute pain in patients with SCD would aid research efforts and enhance clinical care. To meet this need, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks public–private partnership with the U.S. Food and Drug Administration, the American Pain Society, and the American Academy of Pain Medicine formed the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks–American Pain Society–American Academy of Pain Medicine Pain Taxonomy initiative. One of the goals of this initiative was to develop taxonomies for acute pain disorders, including SCD. To accomplish this, a working group of experts in SCD and pain was convened. Based on available literature and expert opinion, the working group used a 5-dimenional structure (diagnostic criteria, common features, modulating factors, impact/functional consequences, and putative mechanisms) to develop an acute pain taxonomy that is specific to SCD. As part of this, a set of 4 diagnostic criteria, with 2 modifiers to account for the influence of chronic pain, are proposed to define the types of acute pain observed in patients with SCD. Perspective: This article presents a taxonomy for acute pain in patients with SCD. This taxonomy could help to standardize definitions of acute pain in clinical studies of patients with SCD.
AB - Acute pain episodes are the most common complication in patients with sickle cell disease (SCD). Classically attributed to vaso-occlusion, recent insights suggest that chronic pain may also contribute to the pathogenesis of acute pain episodes, which adds complexity to their diagnosis and management. A taxonomy, or classification system, for acute pain in patients with SCD would aid research efforts and enhance clinical care. To meet this need, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks public–private partnership with the U.S. Food and Drug Administration, the American Pain Society, and the American Academy of Pain Medicine formed the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks–American Pain Society–American Academy of Pain Medicine Pain Taxonomy initiative. One of the goals of this initiative was to develop taxonomies for acute pain disorders, including SCD. To accomplish this, a working group of experts in SCD and pain was convened. Based on available literature and expert opinion, the working group used a 5-dimenional structure (diagnostic criteria, common features, modulating factors, impact/functional consequences, and putative mechanisms) to develop an acute pain taxonomy that is specific to SCD. As part of this, a set of 4 diagnostic criteria, with 2 modifiers to account for the influence of chronic pain, are proposed to define the types of acute pain observed in patients with SCD. Perspective: This article presents a taxonomy for acute pain in patients with SCD. This taxonomy could help to standardize definitions of acute pain in clinical studies of patients with SCD.
KW - Sickle cell disease
KW - pain
KW - taxonomy
UR - http://www.scopus.com/inward/record.url?scp=85059872795&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059872795&partnerID=8YFLogxK
U2 - 10.1016/j.jpain.2018.12.003
DO - 10.1016/j.jpain.2018.12.003
M3 - Article
C2 - 30578848
AN - SCOPUS:85059872795
SN - 1526-5900
VL - 20
SP - 746
EP - 759
JO - Journal of Pain
JF - Journal of Pain
IS - 7
ER -