Anal dysplasia in HIV-infected women: a commentary on the field

Catherine Godfrey, Cynthia S. Firnhaber, Gypsyamber D'Souza, Isabelle Heard

Research output: Contribution to journalReview articlepeer-review

Abstract

Anal cancer may be an emerging clinical problem in HIV-infected women particularly in resource-limited settings. Human papillomavirus (HPV) infection is a precursor to anal cancer and is prevalent in HIV-infected women, but the natural history of HPV infection and anal cancer precursors is not well described in this population. It is not known which specific dysplastic lesions in the anus are most likely to progress, and whether treatment of high grade squamous intraepithelial lesion reduces the incidence of anal cancer in women. Cervical HPV infection and associated lesions may be related to the pathogenesis and natural history of anal disease. Cervical screening is resource intensive but some limited infrastructure exists in most areas where cervical cancer is prevalent. Anal screening, however is not performed. It may be that the infrastructure for cervical screening may be leveraged in developing the appropriate research, screening and treatment tools for anal dysplasia.

Original languageEnglish (US)
Pages (from-to)543-549
Number of pages7
JournalInternational Journal of STD and AIDS
Volume28
Issue number6
DOIs
StatePublished - May 1 2017

Keywords

  • HIV
  • human papillomavirus
  • women

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

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