TY - JOUR
T1 - Anal dysplasia in HIV-infected women
T2 - a commentary on the field
AU - Godfrey, Catherine
AU - Firnhaber, Cynthia S.
AU - D'Souza, Gypsyamber
AU - Heard, Isabelle
N1 - Publisher Copyright:
© 2015, © The Author(s) 2015.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Anal cancer may be an emerging clinical problem in HIV-infected women particularly in resource-limited settings. Human papillomavirus (HPV) infection is a precursor to anal cancer and is prevalent in HIV-infected women, but the natural history of HPV infection and anal cancer precursors is not well described in this population. It is not known which specific dysplastic lesions in the anus are most likely to progress, and whether treatment of high grade squamous intraepithelial lesion reduces the incidence of anal cancer in women. Cervical HPV infection and associated lesions may be related to the pathogenesis and natural history of anal disease. Cervical screening is resource intensive but some limited infrastructure exists in most areas where cervical cancer is prevalent. Anal screening, however is not performed. It may be that the infrastructure for cervical screening may be leveraged in developing the appropriate research, screening and treatment tools for anal dysplasia.
AB - Anal cancer may be an emerging clinical problem in HIV-infected women particularly in resource-limited settings. Human papillomavirus (HPV) infection is a precursor to anal cancer and is prevalent in HIV-infected women, but the natural history of HPV infection and anal cancer precursors is not well described in this population. It is not known which specific dysplastic lesions in the anus are most likely to progress, and whether treatment of high grade squamous intraepithelial lesion reduces the incidence of anal cancer in women. Cervical HPV infection and associated lesions may be related to the pathogenesis and natural history of anal disease. Cervical screening is resource intensive but some limited infrastructure exists in most areas where cervical cancer is prevalent. Anal screening, however is not performed. It may be that the infrastructure for cervical screening may be leveraged in developing the appropriate research, screening and treatment tools for anal dysplasia.
KW - HIV
KW - human papillomavirus
KW - women
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U2 - 10.1177/0956462415615764
DO - 10.1177/0956462415615764
M3 - Review article
C2 - 26538554
AN - SCOPUS:85018945580
SN - 0956-4624
VL - 28
SP - 543
EP - 549
JO - International Journal of STD and AIDS
JF - International Journal of STD and AIDS
IS - 6
ER -