TY - JOUR
T1 - Anal duct carcinoma in a 70-year-old male with a history of prostate cancer
AU - Meriden, Zina
AU - Montgomery, Elizabeth A.
PY - 2011/8/1
Y1 - 2011/8/1
N2 - Anal duct (gland) carcinoma is a rare, under-recognized neoplasm of the anal canal. Histologically, it consists of haphazardly oriented neoplastic glands that proliferate beneath intact non-neoplastic squamous epithelium. Frequently, Pagetoid-like spread into the overlying squamous epithelium may be observed. Anal duct carcinoma is characteristically CK7+/CK20- by immunohistochemistry. We report a case of anal duct carcinoma diagnosed in a 70-year-old male with a history of treated prostate cancer. The epidemiology, clinical presentation, histologic features, differential diagnosis, treatment, and prognosis of anal duct carcinoma are discussed.
AB - Anal duct (gland) carcinoma is a rare, under-recognized neoplasm of the anal canal. Histologically, it consists of haphazardly oriented neoplastic glands that proliferate beneath intact non-neoplastic squamous epithelium. Frequently, Pagetoid-like spread into the overlying squamous epithelium may be observed. Anal duct carcinoma is characteristically CK7+/CK20- by immunohistochemistry. We report a case of anal duct carcinoma diagnosed in a 70-year-old male with a history of treated prostate cancer. The epidemiology, clinical presentation, histologic features, differential diagnosis, treatment, and prognosis of anal duct carcinoma are discussed.
KW - Anal duct carcinoma
KW - Anal gland carcinoma
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U2 - 10.1016/j.mpdhp.2011.06.005
DO - 10.1016/j.mpdhp.2011.06.005
M3 - Article
AN - SCOPUS:79960898582
SN - 1756-2317
VL - 17
SP - 362
EP - 365
JO - Current Diagnostic Pathology
JF - Current Diagnostic Pathology
IS - 8
ER -