Anal duct carcinoma: A report of 5 cases

Research output: Contribution to journalArticle

Abstract

Anal duct carcinoma (ADC) is a rare lesion composed of glands undermining non-neoplastic squamous epithelium. We describe the clinicopathologic characteristics and follow-up of 5 cases of ADC. Four definitive cases had tissue available for immunohistochemistry (IHC; CK7, CK20, prostate-specific antigen [PSA], estrogen/progesterone receptors [ER/PR], and p16) and in situ hybridization (ISH) for high-risk human papillomavirus (HR-HPV); a fifth case, with a history of ADC, had limited tissue for immunolabeling with only CK7, CK20, and p16. The mean patient age was 69.8 years. All 5 cases were CK7-positive and p16-negative. Four of 5 cases were CK20-negative. All cases with sufficient tissue (4/4) were negative for HR-HPV by ISH, PSA-negative (men), and ER/PR-negative (women). Four of 5 patients had previous malignancies, and in all 4 cases with sufficient tissue, metastasis was excluded with IHC. Of 5 patients, 3 developed metastases, whereas 2 had isolated local recurrences. ADCs are neoplasms with metastatic potential and can result in poor outcomes.

Original languageEnglish (US)
Pages (from-to)216-220
Number of pages5
JournalHuman pathology
Volume43
Issue number2
DOIs
StatePublished - Feb 1 2012

Keywords

  • Anal duct carcinoma
  • Anal gland carcinoma
  • Human papilloma virus
  • Rare carcinomas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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