An update on Zika vaccine developments

Anna P Durbin, Annelies Wilder-Smith

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: The devastating consequences of congenital Zika virus (ZIKV) infection led to a global response directed toward a better understanding of the epidemiology and pathogenesis of ZIKV and to efforts at vaccine development. As a result, there are currently 45 ZIKV vaccine candidates in development. Areas covered: Both traditional (purified inactivated, live attenuated, viral-vectored, recombinant sub-unit) and novel (DNA, self-replicating RNA, mRNA) vaccine platforms are being utilized. For emergency use, vaccines that are appropriate for women of child-bearing age (including pregnant women) are being developed. Live vaccines that may be contraindicated in pregnancy are also in development for potential inclusion in national immunization programmes in childhood or pre-teenage age groups. WHO developed a target product profile for Zika vaccines for use in an emergency. Expert commentary: Although ZIKV vaccine development had a quick head start, further development may be hampered because of the inability to conduct large efficacy trials with the decline in cases globally and unpredictability of new outbreaks. Furthermore, there are complex ethical issues involved in conducting efficacy trials in pregnant women.

Original languageEnglish (US)
Pages (from-to)781-787
Number of pages7
JournalExpert Review of Vaccines
Volume16
Issue number8
DOIs
StatePublished - Aug 3 2017

Keywords

  • chimeric vaccines
  • dengue
  • DNA vaccines
  • live attenuated virus
  • mRNA vaccines
  • purified inactivated virus
  • sub-unit protein
  • vaccine development
  • Zika
  • Zika vaccine

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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