An Update on the Utility of Coronary Artery Calcium Scoring for Coronary Heart Disease and Cardiovascular Disease Risk Prediction

Sina Kianoush, Mahmoud Al Rifai, Miguel Cainzos-Achirica, Priya Umapathi, Garth Graham, Roger S Blumenthal, Khurram Nasir, Michael Blaha

Research output: Contribution to journalReview article

Abstract

Estimating cardiovascular disease (CVD) risk is necessary for determining the potential net benefit of primary prevention pharmacotherapy. Risk estimation relying exclusively on traditional CVD risk factors may misclassify risk, resulting in both undertreatment and overtreatment. Coronary artery calcium (CAC) scoring personalizes risk prediction through direct visualization of calcified coronary atherosclerotic plaques and provides improved accuracy for coronary heart disease (CHD) or CVD risk estimation. In this review, we discuss the most recent studies on CAC, which unlike historical studies, focus sharply on clinical application. We describe the MESA CHD risk calculator, a recently developed CAC-based 10-year CHD risk estimator, which can help guide preventive therapy allocation by better identifying both high- and low-risk individuals. In closing, we discuss calcium density, regional distribution of CAC, and extra-coronary calcification, which represent the future of CAC and CVD risk assessment research and may lead to further improvements in risk prediction.

Original languageEnglish (US)
Pages (from-to)13
Number of pages1
JournalCurrent Atherosclerosis Reports
Volume18
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Coronary Disease
Coronary Vessels
Cardiovascular Diseases
Calcium
Atherosclerotic Plaques
Primary Prevention
Coronary Artery Disease
Drug Therapy
Research

Keywords

  • Cardiovascular disease
  • Coronary artery calcium
  • Coronary heart disease
  • Primary prevention
  • Risk assessment
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

An Update on the Utility of Coronary Artery Calcium Scoring for Coronary Heart Disease and Cardiovascular Disease Risk Prediction. / Kianoush, Sina; Rifai, Mahmoud Al; Cainzos-Achirica, Miguel; Umapathi, Priya; Graham, Garth; Blumenthal, Roger S; Nasir, Khurram; Blaha, Michael.

In: Current Atherosclerosis Reports, Vol. 18, No. 3, 01.03.2016, p. 13.

Research output: Contribution to journalReview article

Kianoush, Sina ; Rifai, Mahmoud Al ; Cainzos-Achirica, Miguel ; Umapathi, Priya ; Graham, Garth ; Blumenthal, Roger S ; Nasir, Khurram ; Blaha, Michael. / An Update on the Utility of Coronary Artery Calcium Scoring for Coronary Heart Disease and Cardiovascular Disease Risk Prediction. In: Current Atherosclerosis Reports. 2016 ; Vol. 18, No. 3. pp. 13.
@article{7dab7b4d5e77489faaf374cb7cffaff0,
title = "An Update on the Utility of Coronary Artery Calcium Scoring for Coronary Heart Disease and Cardiovascular Disease Risk Prediction",
abstract = "Estimating cardiovascular disease (CVD) risk is necessary for determining the potential net benefit of primary prevention pharmacotherapy. Risk estimation relying exclusively on traditional CVD risk factors may misclassify risk, resulting in both undertreatment and overtreatment. Coronary artery calcium (CAC) scoring personalizes risk prediction through direct visualization of calcified coronary atherosclerotic plaques and provides improved accuracy for coronary heart disease (CHD) or CVD risk estimation. In this review, we discuss the most recent studies on CAC, which unlike historical studies, focus sharply on clinical application. We describe the MESA CHD risk calculator, a recently developed CAC-based 10-year CHD risk estimator, which can help guide preventive therapy allocation by better identifying both high- and low-risk individuals. In closing, we discuss calcium density, regional distribution of CAC, and extra-coronary calcification, which represent the future of CAC and CVD risk assessment research and may lead to further improvements in risk prediction.",
keywords = "Cardiovascular disease, Coronary artery calcium, Coronary heart disease, Primary prevention, Risk assessment, Statins",
author = "Sina Kianoush and Rifai, {Mahmoud Al} and Miguel Cainzos-Achirica and Priya Umapathi and Garth Graham and Blumenthal, {Roger S} and Khurram Nasir and Michael Blaha",
year = "2016",
month = "3",
day = "1",
doi = "10.1007/s11883-016-0565-6",
language = "English (US)",
volume = "18",
pages = "13",
journal = "Current Atherosclerosis Reports",
issn = "1523-3804",
publisher = "Current Medicine Group",
number = "3",

}

TY - JOUR

T1 - An Update on the Utility of Coronary Artery Calcium Scoring for Coronary Heart Disease and Cardiovascular Disease Risk Prediction

AU - Kianoush, Sina

AU - Rifai, Mahmoud Al

AU - Cainzos-Achirica, Miguel

AU - Umapathi, Priya

AU - Graham, Garth

AU - Blumenthal, Roger S

AU - Nasir, Khurram

AU - Blaha, Michael

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Estimating cardiovascular disease (CVD) risk is necessary for determining the potential net benefit of primary prevention pharmacotherapy. Risk estimation relying exclusively on traditional CVD risk factors may misclassify risk, resulting in both undertreatment and overtreatment. Coronary artery calcium (CAC) scoring personalizes risk prediction through direct visualization of calcified coronary atherosclerotic plaques and provides improved accuracy for coronary heart disease (CHD) or CVD risk estimation. In this review, we discuss the most recent studies on CAC, which unlike historical studies, focus sharply on clinical application. We describe the MESA CHD risk calculator, a recently developed CAC-based 10-year CHD risk estimator, which can help guide preventive therapy allocation by better identifying both high- and low-risk individuals. In closing, we discuss calcium density, regional distribution of CAC, and extra-coronary calcification, which represent the future of CAC and CVD risk assessment research and may lead to further improvements in risk prediction.

AB - Estimating cardiovascular disease (CVD) risk is necessary for determining the potential net benefit of primary prevention pharmacotherapy. Risk estimation relying exclusively on traditional CVD risk factors may misclassify risk, resulting in both undertreatment and overtreatment. Coronary artery calcium (CAC) scoring personalizes risk prediction through direct visualization of calcified coronary atherosclerotic plaques and provides improved accuracy for coronary heart disease (CHD) or CVD risk estimation. In this review, we discuss the most recent studies on CAC, which unlike historical studies, focus sharply on clinical application. We describe the MESA CHD risk calculator, a recently developed CAC-based 10-year CHD risk estimator, which can help guide preventive therapy allocation by better identifying both high- and low-risk individuals. In closing, we discuss calcium density, regional distribution of CAC, and extra-coronary calcification, which represent the future of CAC and CVD risk assessment research and may lead to further improvements in risk prediction.

KW - Cardiovascular disease

KW - Coronary artery calcium

KW - Coronary heart disease

KW - Primary prevention

KW - Risk assessment

KW - Statins

UR - http://www.scopus.com/inward/record.url?scp=84982835395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982835395&partnerID=8YFLogxK

U2 - 10.1007/s11883-016-0565-6

DO - 10.1007/s11883-016-0565-6

M3 - Review article

VL - 18

SP - 13

JO - Current Atherosclerosis Reports

JF - Current Atherosclerosis Reports

SN - 1523-3804

IS - 3

ER -