TY - JOUR
T1 - An update on the rapid advances in malaria parasite cell biology
AU - Coppens, Isabelle
AU - Sullivan, David J.
AU - Prigge, Sean T.
N1 - Funding Information:
This work was supported by the National Institutes of Health grants AI065853 (S.T.P.) and AI045774 (D.S.), and a Malaria Pilot Grant from the Malaria Research Institute (I.C.). Generous support for the RAM2009 meeting including endemic scientist travelling fellowships was provided by GlaxoSmithKline, Novartis, and the Bloomberg Family Foundation.
PY - 2010/6
Y1 - 2010/6
N2 - Recent years have seen rapid advances in our understanding of malaria parasite cell biology. Some of this progress has been the result of developments in genetic techniques, advances in imaging technology, and new molecular tools. We focus on three aspects of parasite cell biology: (i) plastid metabolism, (ii) sporozoite biology, and (iii) protein transport to and from the host erythrocyte. In each case recent work has led to a deeper understanding of parasite biology, often at the expense of previously accepted paradigms. These studies also highlight the impediments, technical and otherwise, that will have to be overcome for continued rapid progress in these fields.
AB - Recent years have seen rapid advances in our understanding of malaria parasite cell biology. Some of this progress has been the result of developments in genetic techniques, advances in imaging technology, and new molecular tools. We focus on three aspects of parasite cell biology: (i) plastid metabolism, (ii) sporozoite biology, and (iii) protein transport to and from the host erythrocyte. In each case recent work has led to a deeper understanding of parasite biology, often at the expense of previously accepted paradigms. These studies also highlight the impediments, technical and otherwise, that will have to be overcome for continued rapid progress in these fields.
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U2 - 10.1016/j.pt.2010.03.007
DO - 10.1016/j.pt.2010.03.007
M3 - Review article
C2 - 20382563
AN - SCOPUS:77952584312
SN - 1471-4922
VL - 26
SP - 305
EP - 310
JO - Trends in parasitology
JF - Trends in parasitology
IS - 6
ER -