An update on research priorities in hydrocephalus: Overview of the third National Institutes of Health-sponsored symposium "opportunities for Hydrocephalus Research: Pathways to Better Outcomes"

James P. McAllister, Michael A. Williams, Marion L. Walker, John R W Kestle, Norman R. Relkin, Amy M. Anderson, Paul H. Gross, Samuel R. Browd, Stephen A. Back, Mohit Bhandari, William G. Bradley, Jerold Chun, Paige T. Church, Thomas J. Clement, Marc R. Del Bigio, Maureen Dennis, William B. Dobyns, Richard J. Edwards, Jack M. Fletcher, Antonio J. Jimenez & 12 others Abhaya V. Kulkarni, David D. Limbrick, Barry Lutz, Jill A. Morris, Richard S. Morrison, Jay Riva-Cambrin, Esteban Rodriguez, Mark Wagshul, Benjamin Warf, Laurence Watkins, David A. Watson, Andrew Zabel

Research output: Contribution to journalArticle

Abstract

Building on previous National Institutes of Health-sponsored symposia on hydrocephalus research, "Opportunities for Hydrocephalus Research: Pathways to Better Outcomes" was held in Seattle, Washington, July 9-11, 2012. Plenary sessions were organized into four major themes, each with two subtopics: Causes of Hydrocephalus (Genetics and Pathophysiological Modifications); Diagnosis of Hydrocephalus (Biomarkers and Neuroimaging); Treatment of Hydrocephalus (Bioengineering Advances and Surgical Treatments); and Outcome in Hydrocephalus (Neuropsychological and Neurological). International experts gave plenary talks, and extensive group discussions were held for each of the major themes. The conference emphasized patient-centered care and translational research, with the main objective to arrive at a consensus on priorities in hydrocephalus that have the potential to impact patient care in the next 5 years. The current state of hydrocephalus research and treatment was presented, and the following priorities for research were recommended for each theme. 1) Causes of Hydrocephalus-CSF absorption, production, and related drug therapies; pathogenesis of human hydrocephalus; improved animal and in vitro models of hydrocephalus; developmental and macromolecular transport mechanisms; biomechanical changes in hydrocephalus; and age-dependent mechanisms in the development of hydrocephalus. 2) Diagnosis of Hydrocephalus-implementation of a standardized set of protocols and a shared repository of technical information; prospective studies of multimodal techniques including MRI and CSF biomarkers to test potential pharmacological treatments; and quantitative and cost-effective CSF assessment techniques. 3) Treatment of Hydrocephalus-improved bioengineering efforts to reduce proximal catheter and overall shunt failure; external or implantable diagnostics and support for the biological infrastructure research that informs these efforts; and evidencebased surgical standardization with longitudinal metrics to validate or refute implemented practices, procedures, or tests. 4) Outcome in Hydrocephalus-development of specific, reliable batteries with metrics focused on the hydrocephalic patient; measurements of neurocognitive outcome and quality-of-life measures that are adaptable, trackable across the growth spectrum, and applicable cross-culturally; development of comparison metrics against normal aging and sensitive screening tools to diagnose idiopathic normal pressure hydrocephalus against appropriate normative age-based data; better understanding of the incidence and prevalence of hydrocephalus within both pediatric and adult populations; and comparisons of aging patterns in adults with hydrocephalus against normal aging patterns.

Original languageEnglish (US)
Pages (from-to)1427-1438
Number of pages12
JournalJournal of Neurosurgery
Volume123
Issue number6
DOIs
StatePublished - Dec 1 2015

Fingerprint

National Institutes of Health (U.S.)
Hydrocephalus
Bioengineering
Biological Markers
Normal Pressure Hydrocephalus
Patient-Centered Care
Translational Medical Research
Neuroimaging
Catheters
Quality of Life
Prospective Studies
Pharmacology
Pediatrics
Costs and Cost Analysis
Drug Therapy
Incidence
In Vitro Techniques

Keywords

  • Conference
  • Hydrocephalus
  • National Institutes of Health
  • Research
  • Symposium

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Medicine(all)

Cite this

An update on research priorities in hydrocephalus : Overview of the third National Institutes of Health-sponsored symposium "opportunities for Hydrocephalus Research: Pathways to Better Outcomes". / McAllister, James P.; Williams, Michael A.; Walker, Marion L.; Kestle, John R W; Relkin, Norman R.; Anderson, Amy M.; Gross, Paul H.; Browd, Samuel R.; Back, Stephen A.; Bhandari, Mohit; Bradley, William G.; Chun, Jerold; Church, Paige T.; Clement, Thomas J.; Del Bigio, Marc R.; Dennis, Maureen; Dobyns, William B.; Edwards, Richard J.; Fletcher, Jack M.; Jimenez, Antonio J.; Kulkarni, Abhaya V.; Limbrick, David D.; Lutz, Barry; Morris, Jill A.; Morrison, Richard S.; Riva-Cambrin, Jay; Rodriguez, Esteban; Wagshul, Mark; Warf, Benjamin; Watkins, Laurence; Watson, David A.; Zabel, Andrew.

In: Journal of Neurosurgery, Vol. 123, No. 6, 01.12.2015, p. 1427-1438.

Research output: Contribution to journalArticle

McAllister, JP, Williams, MA, Walker, ML, Kestle, JRW, Relkin, NR, Anderson, AM, Gross, PH, Browd, SR, Back, SA, Bhandari, M, Bradley, WG, Chun, J, Church, PT, Clement, TJ, Del Bigio, MR, Dennis, M, Dobyns, WB, Edwards, RJ, Fletcher, JM, Jimenez, AJ, Kulkarni, AV, Limbrick, DD, Lutz, B, Morris, JA, Morrison, RS, Riva-Cambrin, J, Rodriguez, E, Wagshul, M, Warf, B, Watkins, L, Watson, DA & Zabel, A 2015, 'An update on research priorities in hydrocephalus: Overview of the third National Institutes of Health-sponsored symposium "opportunities for Hydrocephalus Research: Pathways to Better Outcomes"' Journal of Neurosurgery, vol 123, no. 6, pp. 1427-1438. DOI: 10.3171/2014.12.JNS132352

McAllister, James P.; Williams, Michael A.; Walker, Marion L.; Kestle, John R W; Relkin, Norman R.; Anderson, Amy M.; Gross, Paul H.; Browd, Samuel R.; Back, Stephen A.; Bhandari, Mohit; Bradley, William G.; Chun, Jerold; Church, Paige T.; Clement, Thomas J.; Del Bigio, Marc R.; Dennis, Maureen; Dobyns, William B.; Edwards, Richard J.; Fletcher, Jack M.; Jimenez, Antonio J.; Kulkarni, Abhaya V.; Limbrick, David D.; Lutz, Barry; Morris, Jill A.; Morrison, Richard S.; Riva-Cambrin, Jay; Rodriguez, Esteban; Wagshul, Mark; Warf, Benjamin; Watkins, Laurence; Watson, David A.; Zabel, Andrew / An update on research priorities in hydrocephalus : Overview of the third National Institutes of Health-sponsored symposium "opportunities for Hydrocephalus Research: Pathways to Better Outcomes".

In: Journal of Neurosurgery, Vol. 123, No. 6, 01.12.2015, p. 1427-1438.

Research output: Contribution to journalArticle

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